Differentiation of functional adrenoceptors in human and guinea pig airways.

Differentiation of functional adrenoceptors in human and guinea pig airways. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Differentiation of functional adrenoceptors in human and guinea pig airways. Abstract Text:

J Zaagsma,P J van der Heijden,M W van der Schaar,C M Bank,

The nature of the beta-adrenoceptor population(s) mediating direct smooth muscle relaxation, inhibition of antigen-induced histamine release and inhibition of antigen-induced (leukotriene-mediated) smooth muscle contraction of human and guinea pig central and peripheral airways was investigated. Preferential blockade by beta 1- and beta 2-selective antagonists of the relaxation induced by beta 1- and beta 2-selective agonists, respectively, revealed the guinea pig tracheal smooth muscle relaxation to be mediated by both beta 1- and beta 2-adrenoceptors. Using a highly beta 2-selective antagonist, the NE-induced relaxation was split up biphasically into a beta 1- and a beta 2-component. In contrast, no such differential blockade was observed with the relaxation of the guinea pig lung parenchyma strip, neither with the human tracheal, main bronchus and respiratory bronchiolus smooth muscle, which are all mediated by homogeneous beta 2-adrenoceptor populations. Only in the guinea pig trachea did neuronal and extraneuronal uptake inhibitors produce pronounced left shifts of the NE- and ISO-induced relaxation curves, respectively, suggesting a causal relationship between noradrenergic innervation and the presence of the beta 1-adrenoceptor subpopulation in the airways. Using the same techniques, it was established that inhibition of antigen-induced histamine release from guinea pig lung and tracheal mast cells is mediated by homogeneous beta 2-adrenoceptor populations as well. In contrast to catecholamines, non-catecholamine beta-agonists such as fenoterol, clenbuterol and zinterol had a substantially higher apparent affinity for the inhibition of the anaphylactic (leukotriene-mediated) guinea pig tracheal contraction than for the inhibition of histamine release; the same was true for lung tissue, though the difference was less pronounced. With some non-catecholamine beta-agonists considerable selectivity both in central and peripheral airway preparations was observed for the inhibition of anaphylactic contraction as compared with smooth muscle relaxation.

Differentiation of functional adrenoceptors in human and guinea pig airways. Publishing Authors By Initials

J Zaagsma,PJ van der Heijden,MW van der Schaar,CM Bank,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

PUBMED ID PMID:

MEDLINE DATE:

Differentiation of functional adrenoceptors in human and guinea pig airways. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of respiratory diseases. Suppleme

VOLUME: 135

Page Numbers: 16-33

Journal Abbreviation:

ISSN: 0106-4347

DAY: 21

MONTH: 02

YEAR: 1984

Differentiation of functional adrenoceptors in human and guinea pig airways. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8010618

Differentiation of functional adrenoceptors in human and guinea pig airways. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: physiology

Chemical & Substance for Abstract: Differentiation of functional adrenoceptors in human and guinea pig airways. Information

Substance Name: Ovalbumin

Registry Number: 9006-59-1

Grant and Affiliation Information for Differentiation of functional adrenoceptors in human and guinea pig airways.

AFFILIATION:

Country: DENMARK

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Respir Dis Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Differentiation of functional adrenoceptors in human and guinea pig airways Related Publications

• A case of murine typhus associated with large vessel infarct of the spleen.
• An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.
• Analysis of handling noises on wound strings.
• Brainstem auditory evoked potentials in migraine after Rausedyl provocation.
• Cerebral ischemia. I. Current angiographic techniques, complications, and safety.
• Diagnostic problems in cancer of the pancreas.
• Differentiation of functional adrenoceptors in human and guinea pig airways.
• Interpretation of positive edrophonium (Tensilon) test in patients with end-stage renal disease.
• Letter: Metoclopramide and facial dyskinesia.
• Loudspeaker.
• MR findings in subacute combined degeneration of the spinal cord: a case of reversible cervical myelopathy.
• On the road to gene therapy for beta-thalassemia and sickle cell anemia.
• Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.
• Surgery in amoebic colitis.
• Synovial VLA-1+ T cells display an oligoclonal and partly distinct repertoire in rheumatoid and psoriatic arthritis.
• The cardiovascular effects of the thiazolidinediones: a review of the clinical data.
• The immunofluorescent tumor imprint technique. IV. The significance of "thready" nuclear immunofluorescence.
• Very late antigen-1 in psoriasis: an immunohistochemical study.
• Virus hepatitis.
• [A new use of the Boero method.]
• [Combined hyason infiltration-ultrasonic treatment in gynecology.]
• [Experiences with metroscopy.]
• [Fractionation of centrifugated spermatozoas with special reference to their form and motility]
• [Mucor mycosis of the endometrium.]
• [On the role of trichomonas infection of the sperm in sterility]
• [Pregnancy following artificial insemination in cases of paternal oligospermia]
• [Spermicidal effect of the vaginal environment]