Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy.

Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Research Abstract Details 

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Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Abstract Text:

Patrick Weybright,Pia C Sundgren,Pavel Maly,Diana Gomez Hassan,Bin Nan,Suzan Rohrer,Larry Junck,

OBJECTIVE: The purpose of our study was to explore the feasibility and utility of 2D chemical shift imaging (CSI) MR spectroscopy in the evaluation of new areas of contrast enhancement at the site of a previously treated brain neoplasm. MATERIALS AND METHODS: Two-dimensional CSI (point-resolved spectroscopy sequence [PRESS]; TR/TE, 1,500/144) was performed in 29 consecutive patients (4-54 years old; mean age, 34 years) who had a new contrast-enhancing lesion in the vicinity of a previously diagnosed and treated brain neoplasm. Clinical and imaging follow-up, and histopathology in 16 patients, were used as indicators of the identity of a lesion. RESULTS: Diagnostic-quality spectra were obtained in 97% of the patients. The Cho/Cr (choline/creatine) and Cho/NAA (choline/N-acetyl aspartate) ratios were significantly higher, and the NAA/Cr ratios significantly lower, in tumor than in radiation injury (all three differences, p < 0.0001). The Cho/Cr and Cho/NAA ratios were significantly higher in radiation injury than in normal-appearing white matter (p < 0.0003 and p < 0.0001, respectively), whereas NAA/Cr ratios were not different (p = 0.075). Mean Cho/Cr ratios were 2.52 for tumor, 1.57 for radiation injury, and 1.14 for normal-appearing white matter. Mean Cho/NAA ratios were 3.48, 1.31, 0.79, and mean NAA/Cr ratios were 0.79, 1.22, and 1.38, respectively. When values greater than 1.8 for either Cho/Cr or Cho/NAA ratios were considered evidence of tumor, 27 of 28 patients could be correctly classified. CONCLUSION: Two-dimensional CSI MR spectroscopy can differentiate tumor from radiation injury in patients with recurrent contrast-enhancing intracranial lesions. In these lesions, the Cho/NAA and Cho/Cr ratios may be the best numeric discriminators.

Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Publishing Authors By Initials

P Weybright,PC Sundgren,P Maly,DG Hassan,B Nan,S Rohrer,L Junck,

For similar disorders of environmental origin: wounds and injuries: radiation injuries research abstracts see: disorders of environmental origin: wounds and injuries: radiation injuries research

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Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 185

Page Numbers: 1471-6

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ISSN: 0361-803X

DAY: 15

MONTH: Dec

YEAR: 2005

Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Keywords Mesh Terms:

KEYWORDS: Radiation Injuries

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. Information

Substance Name: N-acetylaspartate

Registry Number: 997-55-7

Grant and Affiliation Information for Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy.

AFFILIATION: Department of Radiology, University of Michigan, Ann Arbor, MI 48109-0030, USA.

Country: United States

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MEDLINETA: AJR Am J Roentgenol

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