Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy.

Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Research Abstract Details 

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Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Abstract Text:

The incidence of thyroid cancer in childhood amounts to approximately 0,5/100.000/year. However, after exposure to ionizing irradiation, the incidence may increase more than 20 fold. In children, lymph node metastases of differentiated thyroid cancer are frequent (more than 50%); distant metastases mainly to the lung are seen in 20-30%. The method of choice for the primary diagnosis of thyroid cancer today is ultrasonography with 7,5 - 10 MHz probes, accompanied by fine-needle aspiration biopsy. Differentiated thyroid cancer has to be treated with a multidisciplinary approach comprising total thyroidectomy and lymph node dissection, post-operative radioiodine treatment and TSH-suppression by levothyroxine. The long-term results of this treatment approach are generally good with 10-year survival rates of 95% and higher. The treatment of children with disseminated pulmonary metastases however, may be complicated due to the increased risk of the induction of pulmonary fibrosis by radioiodine.

Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Publishing Authors By Initials

For similar surgical procedures, operative: endocrine surgical procedures: thyroidectomy research abstracts see: surgical procedures, operative: endocrine surgical procedures: thyroidectomy research

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Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric endocrinology reviews : PER

VOLUME: 1 Suppl 2

Page Numbers: 230-5; discussion 235-6

Journal Abbreviation:

ISSN: 1565-4753

DAY: 9

MONTH: Dec

YEAR: 2003

Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Information

Number of References: 32

LANGUAGE: eng

NlmUniqueID: 101202124

Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Keywords Mesh Terms:

KEYWORDS: Thyroidectomy

MESH TERMS: methods

Chemical & Substance for Abstract: Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy. Information

Substance Name: Iodine Radioisotopes

Registry Number: 0

Grant and Affiliation Information for Differentiated thyroid cancer in childhood: pathology, diagnosis, therapy.

AFFILIATION: Clinic and Policlinic for Nuclear Medicine, University of Würzburg. reiners@nuklearmedizin.uni-wuerzburg.de

Country: Israel

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MEDLINETA: Pediatr Endocrinol Rev

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