Differential var gene expression in the organs of patients dying of falciparum malaria.

Differential var gene expression in the organs of patients dying of falciparum malaria. Research Abstract Details 

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Differential var gene expression in the organs of patients dying of falciparum malaria. Abstract Text:

Jacqui Montgomery,Fingani A Mphande,Matthew Berriman,Arnab Pain,Stephen J Rogerson,Terrie E Taylor,Malcolm E Molyneux,Alister Craig,

Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis.

Differential var gene expression in the organs of patients dying of falciparum malaria. Publishing Authors By Initials

J Montgomery,FA Mphande,M Berriman,A Pain,SJ Rogerson,TE Taylor,ME Molyneux,A Craig,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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Differential var gene expression in the organs of patients dying of falciparum malaria. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular microbiology

VOLUME: 65

Page Numbers: 959-67

Journal Abbreviation: Mol. Microbiol.

ISSN: 0950-382X

DAY: 6

MONTH: 07

YEAR: 2007

Differential var gene expression in the organs of patients dying of falciparum malaria. Information

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LANGUAGE: eng

NlmUniqueID: 8712028

Differential var gene expression in the organs of patients dying of falciparum malaria. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: metabolism

Chemical & Substance for Abstract: Differential var gene expression in the organs of patients dying of falciparum malaria. Information

Substance Name: erythrocyte membrane protein 1, Plasmodi

Registry Number: 0

Grant and Affiliation Information for Differential var gene expression in the organs of patients dying of falciparum malaria.

AFFILIATION: Malawi-Liverpool-Wellcome Programme of Clinical Tropical Research, College of Medicine, Blantyre, Malawi. jmontgomery@mlw.medcol.mw

Country: England

AGENCY: United States NIAID

GRANT: R01 AI34969

ACRONYM: AI

MEDLINETA: Mol Microbiol

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