Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function.

Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Research Abstract Details 

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Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Abstract Text:

Yuko Nagata,Hajime Kamijuku,Masaru Taniguchi,Steven Ziegler,Ken-ichiro Seino,Yuko Nagata,Hajime Kamijuku,Masaru Taniguchi,Steven Ziegler,Ken-ichiro Seino,

Asthma is an inflammatory lung disease, in which CD1d-restricted natural killer T (NKT) cells play an important pathogenic role. Also, recent reports indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. Here we examined the relationship between NKT cells and TSLP in a mouse model of asthma. NKT cells express TSLP receptor as well as IL-7 receptor alpha-chain. TSLP acts on NKT cells to preferentially increase their IL-13 production but not IFN-gamma and IL-4. In an allergen-induced asthma model, the development of airway hyperreactivity, a cardinal feature of asthma, was increased in TSLP transgenic mice, whereas this effect was not observed in TSLP transgenic mice lacking NKT cells. Interestingly, in the NKT cell-lacking TSLP transgenic mice, pulmonary eosinophilia and increase in IgE did not improve. Pulmonary lymphocytes from the NKT cell-lacking TSLP transgenic mice produced much less IL-13 upon CD3 stimulation than those from NKT cell-competent TSLP transgenic mice. These resultssuggest that, in allergen-induced asthma, TSLP acts on NKT cells to enhance airway hyperreactivity by upregulating their IL-13 production, whereas eosinophilia and IgE production are not influenced.

Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Publishing Authors By Initials

Y Nagata,H Kamijuku,M Taniguchi,S Ziegler,K Seino,Y Nagata,H Kamijuku,M Taniguchi,S Ziegler,K Seino,

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Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International archives of allergy and immunology

VOLUME: 144

Page Numbers: 305-14

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ISSN: 1423-0097

DAY: 23

MONTH: 07

YEAR: 2007

Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Differential role of thymic stromal lymphopoietin in the induction of airway hyperreactivity and Th2 immune response in antigen-induced asthma with respect to natural killer T cell function.

AFFILIATION: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.

Country: Switzerland

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MEDLINETA: Int Arch Allergy Immunol

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