Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling.

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Research Abstract Details 

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Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Abstract Text:

Hang Yin,Julie Chao,Michael Bader,Lee Chao,

We investigated the role of kinin receptors in cardiac remodeling after ischemia/reperfusion (I/R). Bradykinin injection improved cardiac contractility, diastolic function, reduced infarct size and prevented left ventricular thinning after I/R, whereas des-Arg(9)-BK injection had no protective effects. Bradykinin, but not des-Arg(9)-BK, reduced cardiomyocyte apoptosis and increased Akt and GSK-3beta phosphorylation. Furthermore, myocardial infarct size was similar between wild type and B2 knockout mice after I/R, but significantly reduced in kinin B1 receptor knockout mice. These results indicate that the kinin B2 receptor, but not the B1 receptor, protects against I/R-induced cardiac dysfunction by inhibiting apoptosis and limiting ventricular remodeling.

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Publishing Authors By Initials

H Yin,J Chao,M Bader,L Chao,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research

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Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Peptides

VOLUME: 28

Page Numbers: 1383-9

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 25

MONTH: 05

YEAR: 2007

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008690

Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Keywords Mesh Terms:

KEYWORDS: Ventricular Remodeling

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Information

Substance Name: glycogen synthase kinase 3 beta

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling.

AFFILIATION: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425-2211, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL029397-24

ACRONYM: HL

MEDLINETA: Peptides

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