Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells.

Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. Research Abstract Details 

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Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. Abstract Text:

Pejman Soroosh,Shouji Ine,Kazuo Sugamura,Naoto Ishii,

Memory T cells can be divided into effector memory (T(EM)) and central memory (T(CM)) subsets based on their effector function and homing characteristics. Although previous studies have demonstrated that TCR and cytokine signals mediate the generation of the two memory subsets of CD8(+) T cells, the mechanisms for generation of the CD4(+) T(EM) and T(CM) cell subsets are unknown. We found that OX40-deficient mice showed a marked reduction in the number of CD4(+) T(EM) cells, whereas the number of CD4(+) T(CM) cells was normal. Adoptive transfer experiments using Ag-specific CD4(+) T cells revealed that OX40 signals during the priming phase were indispensable for the optimal generation of the CD4(+) T(EM), but not the CD4(+) T(CM) population. In a different transfer experiment with in vitro established CD4(+)CD44(high)CD62L(low) (T(EM) precursor) and CD4(+)CD44(high)CD62L(high) (T(CM) precursor) subpopulations, OX40-KO T(EM) precursor cells could not survive in the recipient mice, whereas wild-type T(EM) precursor cells differentiated into both T(EM) and T(CM) cells. In contrast, T(CM) precursor cells mainly produced T(CM) cells regardless of OX40 signals, implying the dispensability of OX40 for generation of T(CM) cells. Nevertheless, survival of OX40-KO T(EM) cells was partially rescued in lymphopenic mice. During in vitro recall responses, the OX40-KO T(EM) cells that were generated in lymphopenic recipient mice showed impaired cytokine production, suggesting an essential role for OX40 not only on generation but also on effector function of CD4(+) T(EM) cells. Collectively, the present results indicate differential requirements for OX40 signals on generation of CD4(+) T(EM) and T(CM) cells.

Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. Publishing Authors By Initials

P Soroosh,S Ine,K Sugamura,N Ishii,

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Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 5014-23

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Oct

YEAR: 2007

Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells.

AFFILIATION: Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Country: United States

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MEDLINETA: J Immunol

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