Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands.

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Research Abstract Details 

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Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Abstract Text:

Daniel Summerer,Andreas Marx,

DNA polymerases are the key enzymes for DNA synthesis involved in DNA replication, recombination, and repair. These enzymes undergo manifold contacts with the primer-template-substrates reaching up to several nucleotide pairs beyond the catalytic centre. To evaluate these enzyme contacts with the DNA substrates we applied novel synthetic steric probes in functional studies. We found that through application of the these probes valuable insights into DNA polymerase function can be gained, which might be useful for the design of new DNA polymerase-based nucleotide variation detection strategies.

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Publishing Authors By Initials

D Summerer,A Marx,

For similar genetic structures: templates, genetic research abstracts see: genetic structures: templates, genetic research

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Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 124

Page Numbers: 910-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 13

MONTH: Feb

YEAR: 2002

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Keywords Mesh Terms:

KEYWORDS: Templates, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands. Information

Substance Name: DNA Polymerase I

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands.

AFFILIATION: Kekulé-Institut für Organische Chemie und Biochemie Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

Country: United States

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MEDLINETA: J Am Chem Soc

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