Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts.

Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Research Abstract Details 

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Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Abstract Text:

Lily Yan,Rae Silver,

The mechanism whereby brief light exposure resets the mammalian circadian clock in a phase dependent manner is not known, but is thought to involve Per gene expression. At the behavioural level, a light pulse produces phase delays in early subjective night, phase advances in late subjective night, and no phase shifts in mid-subjective night or subjective day. To understand the relationship between Per gene activity and behavioural phase shifts, we examined light-induced mPer1 and mPer2 expression in the suprachiasmatic nucleus (SCN) of the mouse, in the subjective night, with a view to understanding SCN heterogeneity. In the VIP-containing region of the SCN (termed 'core'), light-induced mPer1 expression occurs at all times of the subjective night, while mPer2 induction is seen only in early subjective night. In the remaining regions of the SCN (termed 'shell'), a phase delaying light pulse produces no mPer1 but significant mPer2 expression, while a phase advancing light pulse produces no mPer2 but substantial mPer1 induction. Moreover, following a light pulse during mid-subjective night, neither mPer1 nor mPer2 are induced in the shell. The results reveal that behavioural phase shifts occur only when light-induced Per gene expression spreads from the core to the shell SCN, with mPer1 expression in shell corresponding to phase advances, and mPer2 corresponding to phase delays. The results indicate that the time course and the localization of light-induced Per gene expression in SCN reveals important aspects of intra-SCN communication.

Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Publishing Authors By Initials

L Yan,R Silver,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The European journal of neuroscience

VOLUME: 16

Page Numbers: 1531-40

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 19

MONTH: Oct

YEAR: 2002

Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts.

AFFILIATION: Department of Psychology, Columbia University, New York, NY 10027, USA.

Country: France

AGENCY: United States NINDS

GRANT: NS41069

ACRONYM: NS

MEDLINETA: Eur J Neurosci

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