Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes.

Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. Research Abstract Details 

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Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. Abstract Text:

Yuichiro Yano,Satoshi Hoshide,Joji Ishikawa,Toru Hashimoto,Kazuo Eguchi,Kazuyuki Shimada,Kazuomi Kario,Yuichiro Yano,Satoshi Hoshide,Joji Ishikawa,Toru Hashimoto,Kazuo Eguchi,Kazuyuki Shimada,Kazuomi Kario,

The goal of this study was to examine the association between adiponectin and low-grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection in 157 participants. Overall, as anticipated, 24-hour systolic blood pressure and fasting glucose levels were independent determinants of UAE (beta=0.254 and 0.176, respectively, P<.05). In obese persons (body mass index [BMI] >/=25 kg/m(2); n=63), adiponectin value was a significant negative determinant of UAE (beta=-0.256, P<.05) independent of blood pressure and glucose levels, whereas in nonobese participants (n=94) it was not. In an analysis of BMI and the median value of adiponectin (9.9 microg/mL), UAE was found to be significantly higher in obese persons with low adiponectin levels than in obese persons with high adiponectin levels (9.20 vs 5.11 microg/min; P<.05), even after adjustment for age, sex, blood pressure level, and glucose level. There was an inverse association between adiponectin and low-grade albuminuria in obese nondiabetic persons.

Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. Publishing Authors By Initials

Y Yano,S Hoshide,J Ishikawa,T Hashimoto,K Eguchi,K Shimada,K Kario,Y Yano,S Hoshide,J Ishikawa,T Hashimoto,K Eguchi,K Shimada,K Kario,

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Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical hypertension (Greenwich, Conn.

VOLUME: 9

Page Numbers: 775-82

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ISSN: 1524-6175

DAY: 5

MONTH: Oct

YEAR: 2007

Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes.

AFFILIATION: From the Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Country: United States

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MEDLINETA: J Clin Hypertens (Greenwich)

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