Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice.

Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Research Abstract Details 

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Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Abstract Text:

Ping Cai,Rolf ,M Firoze Khan,Bhupendra S Kaphalia,G A S Ansari,

Trichloroethene (TCE) is an industrial degreasing solvent and widespread environmental contaminant. Exposure to TCE is associated with autoimmunity. The mode of action of TCE is via its oxidative metabolism, and most likely, immunotoxicity is mediated via haptenization of macromolecules and subsequent induction of immune responses. To better understand the role of protein haptenization through TCE metabolism, we immunized MRL+/+ mice with albumin adducts of various TCE reactive intermediates. Serum immunoglobulins and cytokine levels were measured to determine immune responses against haptenized albumin. We found antigen-specific IgG responses of the IgG subtypes IgG(1), IgG(2a), and IgG(2b), with IgG(1) predominating. Serum levels of G-CSF were increased in immunized mice, suggesting macrophage activation. Liver histology revealed lymphocyte infiltration in the lobules and the portal area following immunization with formyl-albumin. Our findings suggest that proteins haptenized by metabolites of TCE may act as neo-antigens that can induce humoral immune responses and T cell-mediated hepatitis.

Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Publishing Authors By Initials

P Cai,R ,MF Khan,BS Kaphalia,GA Ansari,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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MEDLINE DATE:

Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Toxicology and applied pharmacology

VOLUME: 220

Page Numbers: 278-83

Journal Abbreviation:

ISSN: 0041-008X

DAY: 8

MONTH: 02

YEAR: 2007

Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 416575

Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: blood

Chemical & Substance for Abstract: Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice. Information

Substance Name: Trichloroethylene

Registry Number: 79-01-6

Grant and Affiliation Information for Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice.

AFFILIATION: Department of Pathology, University of Texas Medical Branch, Galveston TX 77555-0609, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES011584-04

ACRONYM: ES

MEDLINETA: Toxicol Appl Pharmacol

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