Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta.

Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Research Abstract Details 

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Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Abstract Text:

Regina Trollmann,Karin ,Ralf L Schild,Wolfgang Rascher, ,Regina Trollmann,Karin ,Ralf L Schild,Wolfgang Rascher, ,

OBJECTIVE: Hypoxia-inducible transcription factors (HIFs) have been characterized as the most important regulators of O(2)-dependent gene transcription. We investigated expression of HIF-dependent growth factors and HIF-independent somatotrophic factors in term placenta in response to hypoxic ischemia. STUDY DESIGN: Our cross-sectional in vivo analysis included term placentas of gestations complicated by the following: (1) birth asphyxia (n = 22); (2) chronic hypoxic ischemia (n = 22); and (3) controls (n = 28). Gene expression of leptin, insulin-like growth factor (IGF)-1, IGF-2, ghrelin, and human placental growth hormone (hPGH) were measured by TaqMan reverse transcriptase-polymerase chain reaction. RESULTS: Acute and chronic hypoxia significantly increased leptin messenger ribonucleic acid (mRNA) levels, compared with controls (P < .001). Augmented IGF-2 mRNA levels were present in chronic hypoxia (P < .001) but not in birth asphyxia. IGF-1, ghrelin, and hPGH mRNA levels did not change in relation to hypoxia. CONCLUSION: IGF-2 and leptin are suggested to be involved in adaptive response to hypoxic ischemia in term placenta with differential transcriptional regulation related to the duration of hypoxia.

Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Publishing Authors By Initials

R Trollmann,K ,RL Schild,W Rascher,J ,R Trollmann,K ,RL Schild,W Rascher,J ,

For similar embryonic structures: placenta research abstracts see: embryonic structures: placenta research

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Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of obstetrics and gynecology

VOLUME: 197

Page Numbers: 601.e1-6

Journal Abbreviation: Am. J. Obstet. Gynecol.

ISSN: 1097-6868

DAY: 18

MONTH: Dec

YEAR: 2007

Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Information

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LANGUAGE: eng

NlmUniqueID: 370476

Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Keywords Mesh Terms:

KEYWORDS: Placenta

MESH TERMS: physiology

Chemical & Substance for Abstract: Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Information

Substance Name: Insulin-Like Growth Factor II

Registry Number: 67763-97-7

Grant and Affiliation Information for Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta.

AFFILIATION: Department of Pediatrics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany. regina.trollmann@kinder.imed.uni-erlangen.de

Country: United States

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MEDLINETA: Am J Obstet Gynecol

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