Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication.

Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Research Abstract Details 

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Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Abstract Text:

Beatriz ,Hillary Foster,Yanling Hao,Jay A Levy,

CD8(+) cells from healthy HIV-1-infected individuals suppress human immunodeficiency virus (HIV) replication in infected cells by a non-cytotoxic mechanism. This activity is associated with the production of a soluble CD8(+) cell antiviral factor (CAF) that inhibits viral replication at the level of transcription. Strong CD8(+) cell non-cytotoxic anti-HIV responses (CNARs) correlate with an asymptomatic state and long-term survival of HIV-infected individuals. This antiviral activity is lost when the infected individual advances to disease. In attempts to define the gene(s) mediating CNAR we have evaluated differential gene expression between CD8(+) cells from infected subjects with high CNAR and CD8(+) cells from uninfected controls that lack this activity. The expression analysis, using the Affymetrix GeneChip Human Genome U133 Set, indicated that 18% of the genes were differentially expressed (DE) of which 9.2% were up-regulated. A total of 568 genes were up-regulated with a >2.0-fold difference in expression levels and a >50% concordance of difference call. Stringent selection criteria narrowed down the list to 52 up-regulated 'high confidence genes' (> or = 75% concordance). These genes function in a wide variety of cellular processes and include 13 associated with immunologic activity.

Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Publishing Authors By Initials

B ,H Foster,Y Hao,JA Levy,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Virology

VOLUME: 362

Page Numbers: 217-25

Journal Abbreviation:

ISSN: 0042-6822

DAY: 22

MONTH: 01

YEAR: 2007

Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: genetics

Chemical & Substance for Abstract: Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Differential gene expression in CD8(+) cells from HIV-1-infected subjects showing suppression of HIV replication.

AFFILIATION: Department of Medicine, Division Hematology/Oncology, University of California, San Francisco, CA 94143-1270, USA.

Country: United States

AGENCY: United States NCI

GRANT: T320CA09043

ACRONYM: CA

MEDLINETA: Virology

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