Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Research Abstract Details 

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Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Abstract Text:

K Bae,X Jin,E S Maywood,M H Hastings,S M Reppert,D R Weaver,

The role of mPer1 and mPer2 in regulating circadian rhythms was assessed by disrupting these genes. Mice homozygous for the targeted allele of either mPer1 or mPer2 had severely disrupted locomotor activity rhythms during extended exposure to constant darkness. Clock gene RNA rhythms were blunted in the suprachiasmatic nucleus of mPer2 mutant mice, but not of mPER1-deficient mice. Peak mPER and mCRY1 protein levels were reduced in both lines. Behavioral rhythms of mPer1/mPer3 and mPer2/mPer3 double-mutant mice resembled rhythms of mice with disruption of mPer1 or mPer2 alone, respectively, confirming the placement of mPer3 outside the core circadian clockwork. In contrast, mPer1/mPer2 double-mutant mice were immediately arrhythmic. Thus, mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes.

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Publishing Authors By Initials

K Bae,X Jin,ES Maywood,MH Hastings,SM Reppert,DR Weaver,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuron

VOLUME: 30

Page Numbers: 525-36

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 19

MONTH: May

YEAR: 2001

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.

AFFILIATION: Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA

Country: United States

AGENCY: United States NINDS

GRANT: NS39303

ACRONYM: NS

MEDLINETA: Neuron

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