Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease.

Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Research Abstract Details 

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Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Abstract Text:

Background. The proteins p53, p63 and p73 are known to be overexpressed and to play important roles in the pathogenesis of many tumours, but the expression of p63 and p73 has not previously been investigated in extramammary Paget's disease (EMPD). Aim. To investigate the potential contribution of p53, p63 and p73 in the pathogenesis of EMPD. Methods. In total, 35 paraffin wax-embedded tissue samples from patients with EMPD were examined using immunohistochemical staining for p53, p63 and p73. Results. All of the 35 EMPD specimens, including all 6 invasive EMPD and 2 metastatic lymph-node specimens, showed nuclear overexpression of both p53 and p73. The expression levels (percentage of positive cells) of p53 and p73 (90.66 +/- 12.53% and 80.20 +/- 13.07%) in EMPD were significantly higher than those of normal skin. There was a significant correlation between the expression levels of p53 and p73 in EMPD. In 29 of 35 EMPD specimens, there was no nuclear expression of p63, and weak or moderate staining was found in only 6 specimens. The expression level of p63 in EMPD was significantly less than that in normal skin. Conclusions. Our study shows that the concordant overexpression of p53 and p73 and the decreased expression of p63 may play a pivotal role in the pathogenesis of EMPD. The decreased expression of p63 may play a more important role in the pathogenesis of EMPD than the overexpression of p53 and p73.

Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Publishing Authors By Initials

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Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental dermatology

VOLUME: 33

Page Numbers: 634-40

Journal Abbreviation: Clin. Exp. Dermatol.

ISSN: 1365-2230

DAY: 9

MONTH: 07

YEAR: 2008

Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease. Information

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LANGUAGE: eng

NlmUniqueID: 7606847

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Grant and Affiliation Information for Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease.

AFFILIATION: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Country: England

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MEDLINETA: Clin Exp Dermatol

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