Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate.

Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Research Abstract Details 

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Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Abstract Text:

Wei Zhang,Hua Shen,Long Ma,Baixin Shen,Zicheng Xu,Xinru Wang,

OBJECTIVES: To isolate and identify differentially expressed proteins in fetal rat testis following in utero exposure to di(nbutyl) phthalate (DBP). METHODS: We used the technique of proteomic analysis to compare the testis protein patterns obtained by two-dimensional gel electrophoresis from fetal rats of gestation day 19. RESULTS: We found significant differences in protein spot intensities. Subsequently several of these variant protein spots were identified by mass spectrometry. Peroxiredoxin 6 (Prdx6) was one of them. Prdx6, which expressed a higher level in DBP-treated fetal rat testes compared with normal ones, is a member of the peroxiredoxins family (Prdxs). Recently, Prdx6 had been shown to be important in protecting cells from oxidative injury. Further, immunohistochemical analyses of fetal rat testes sections were made to determine the cellular distribution of this protein, consequently a strong Prdx6 staining was found out primarily in Leydig cells. CONCLUSIONS: The present study had found several differentially regulated proteins and demonstrated the differential expression of Prdx6 in fetal rat testis following in utero exposure to DBP, when compared with controls. Combining the cellular location of Prdx6 and its function in other tissues, the results of this study could provide us with a possibility to interfere the reproductive toxicity of DBP for its specific antioxidant properties in testis tissues.

Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Publishing Authors By Initials

W Zhang,H Shen,L Ma,B Shen,Z Xu,X Wang,

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Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Toxicology

VOLUME: 240

Page Numbers: 86-95

Journal Abbreviation: Toxicology

ISSN: 0300-483X

DAY: 8

MONTH: 08

YEAR: 2007

Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate. Information

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LANGUAGE: eng

NlmUniqueID: 361055

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Grant and Affiliation Information for Differential expression of peroxiredoxin 6 in fetal rat testis following in utero exposure to di(n-butyl) phthalate.

AFFILIATION: Department of Urology, First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China. zhangwei@medmail.com.cn

Country: Ireland

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MEDLINETA: Toxicology

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