Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study.

Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Research Abstract Details 

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Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Abstract Text:

Sean K Lau,Lawrence M Weiss,Peiguo G Chu,

We studied immunohistochemical expression of MUC1, MUC2, and MUC5AC in 194 carcinomas of different primary sites to determine whether differential expression patterns could be used to distinguish different carcinomas. MUC1 was expressed by most (except adrenocortical and hepatocellular carcinomas). MUC2 was expressed infrequently (positive immunoreactivity primarily in tumors of gastrointestinal origin). MUC5AC was expressed by most pancreatic ductal and endocervical adenocarcinomas and a variable number of tumors of the gastrointestinal tract. A MUC1+/MUC2-/MUC5AC- immunophenotype was observed in most breast, lung, kidney, bladder, endometrial, and ovarian carcinomas; MUC1+/MUC2-/MUC5AC+ was characteristic of pancreatic ductal adenocarcinomas and cholangiocarcinomas. Adrenocortical and hepatocellular carcinomas were negative for all mucins. Carcinomas of gastrointestinal origin exhibited variable expression of each mucin examined and no consistent immunoreactivity pattern. Many carcinomas can exhibit distinct MUC1, MUC2, and MUC5AC expression patterns, which might be valuable diagnostically in specific settings (eg, distinguishing cholangiocarcinoma from hepatocellular carcinoma or renal from adrenocortical carcinoma). However the overlapping and heterogeneous patterns of MUC1, MUC2, and MUC5AC expression observed in many tumors, particularly those of gastrointestinal origin, preclude use of these markers in the routine immunohistochemical assessment of carcinomas of an unknown primary site.

Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Publishing Authors By Initials

SK Lau,LM Weiss,PG Chu,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of clinical pathology

VOLUME: 122

Page Numbers: 61-9

Journal Abbreviation: Am. J. Clin. Pathol.

ISSN: 0002-9173

DAY: 30

MONTH: Jul

YEAR: 2004

Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Information

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LANGUAGE: eng

NlmUniqueID: 370470

Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: analysis

Chemical & Substance for Abstract: Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study.

AFFILIATION: Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.

Country: United States

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MEDLINETA: Am J Clin Pathol

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