Differential expression of HPA axis homolog in the skin.

Differential expression of HPA axis homolog in the skin. Research Abstract Details 

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Differential expression of HPA axis homolog in the skin. Abstract Text:

Andrzej Slominski,Jacobo Wortsman,Robert C Tuckey,Ralf Paus,

Human skin expresses elements of the hypothalamo-pituitary-adrenal (HPA) axis including pro-opiomelanocortin (POMC), corticotropin releasing hormone (CRH), the CRH receptor-1 (CRH-R1), key enzymes of corticosteroid synthesis and synthesizes glucocorticoids. Expression of these elements is organized in functional, cell type-specific regulatory loops, which imitate the signaling hierarchy of the HPA axis. In melanocytes and fibroblasts CRH-induced CRH-R1 stimulation upregulates POMC expression and production of ACTH through activation of cAMP dependent pathway(s). Melanocytes respond with enhanced production of cortisol and corticosterone, which is dependent on POMC activity. Fibroblasts respond to CRH and ACTH with enhanced production of corticosterone, but not cortisol, which is produced constitutively. Organ-cultured human scalp hair follicles also show a fully functional HPA axis equivalent, including cortisol synthesis and secretion and negative feedback regulation by cortisol on CRH expression. Thus, differential, CRH-driven responses of defined cutaneous cell populations reproduce key features of the central HPA axis at the tissue/single cell levels.

Differential expression of HPA axis homolog in the skin. Publishing Authors By Initials

A Slominski,J Wortsman,RC Tuckey,R Paus,

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Differential expression of HPA axis homolog in the skin. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular and cellular endocrinology

VOLUME: 265-266

Page Numbers: 143-9

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 29

MONTH: 12

YEAR: 2006

Differential expression of HPA axis homolog in the skin. Information

Number of References: 75

LANGUAGE: eng

NlmUniqueID: 7500844

Differential expression of HPA axis homolog in the skin. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: biosynthesis

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Substance Name: Steroids

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Grant and Affiliation Information for Differential expression of HPA axis homolog in the skin.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of Tennessee, HSC, Memphis, TN 38163, USA. aslominski@utmem.edu

Country: Ireland

AGENCY: United States NIAMS

GRANT: R01 AR052190-01A2

ACRONYM: AR

MEDLINETA: Mol Cell Endocrinol

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