[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta]

[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta] Research Abstract Details 

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[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta] Abstract Text:

Yong-qing Wang,Shu-fang Mi,Jun Li,Yan-ling Wang,Tao Shang,Yong-qing Wang,Shu-fang Mi,Jun Li,Yan-ling Wang,Tao Shang,

OBJECTIVE: To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in preeclampsia placenta and the relation with preeclampsia attacks. METHODS: Forty-four samples from pregnant women with preeclampsia (preeclampsia group), 38 samples from pregnant women with eclampsia, and 49 samples from normal pregnancies (control group) were obtained. We detected the expression of EMMPRIN in placenta by immunohistochemistry and the expression of EMMPRIN mRNA by RT-PCR. RESULTS: (1) EMMPRIN positive expression: in preeclampsia group, the moderate expression rate was 18% (8/44) and the strong positive rate was 9% (4/44); in eclampsia group moderate positive rate was 21% (8/38) and strong positive rate 13% (5/38). The difference of the two groups was insignificant (P > 0.05). In control group the moderate positive rate was 12% (6/49) and strong positive rate 82% (40/49), the difference from the preeclampsia and the eclampsia groups was significant (P < 0.001). (2) EMMPRIN mRNA expression: in preeclampsia group EMMPRIN mRNA expression in term placenta (37 - 40 gestational weeks) was 0.342 +/- 0.002, and in eclampsia group 0.344 +/- 0.023; the difference between the two groups was insignificant (P > 0.05). In control group EMMPRIN mRNA expression in term placenta (37 - 40 gestational weeks) was 0.872 +/- 0.094, the differences between the control group and preeclampsia and eclampsia groups were both significant (P < 0.001). CONCLUSION: The decrease in the expression of EMMPRIN in placenta is an important cause of preeclampsia onset; expression rate of EMMPRIN may serve as an indicator in predicting preeclampsia.

[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta] Publishing Authors By Initials

YQ Wang,SF Mi,J Li,YL Wang,T Shang,YQ Wang,SF Mi,J Li,YL Wang,T Shang,

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[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua fu chan ke za zhi

VOLUME: 41

Page Numbers: 436-9

Journal Abbreviation: Zhonghua Fu Chan Ke Za Zhi

ISSN: 0529-567X

DAY: 6

MONTH: Jul

YEAR: 2006

[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta] Information

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LANGUAGE: chi

NlmUniqueID: 16210370

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AFFILIATION: Department of Obstetrics and Gynecology, Second Affiliated Hospital, China Medical Univercity, Shenyang 110004, China.

Country: China

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MEDLINETA: Zhonghua Fu Chan Ke Za Zhi

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