Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue.

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Abstract Text:

A Tatsuguchi,T Kishida,S Fujimori,S Tanaka,K Gudis,S Shinji,K Furukawa,T Tajiri,Y Sugisaki,Y Fukuda,C Sakamoto,

Background Both adenomatous polyposis coli (APC) gene mutation and cyclo-oxygenase (COX)-2 are thought to play key roles in colorectal carcinogenesis. Nuclear accumulation of beta-catenin results from APC gene mutation, which leads to enhanced transcription and activation of target genes, including cyclin D1. In vitro studies suggest that Cox-2 transcription is directly regulated by beta-catenin/TCF complexes. Aim To investigate the relationship between cellular localization of beta-catenin and COX-2 in colorectal cancer. Methods We performed immunohistochemical analysis of beta-catenin, cyclin D1 and COX-2 expression in 50 resected colorectal cancer cases. Results The proportion of cases positive for cyclin D1 was higher in nuclear beta-catenin-positive cases than in negative cases (P < 0.001). Serial sections revealed that the co-localization of cyclin D1 and nuclear beta-catenin was most frequently evident in the tumour cells at the advancing margin of invasive carcinoma. Conversely, there was no association between COX-2 and nuclear beta-catenin expression, either topographically or statistically. The staining patterns for COX-2 and nuclear beta-catenin differed; COX-2 was diffuse and homogeneous, whereas nuclear beta-catenin was focal and preferentially distributed at the invasive margin of cancer cells. Conclusions These two important modulators of colorectal tumourigenesis are differentially expressed. Cox-2 and beta-catenin transcription may be activated by different pathways.

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Publishing Authors By Initials

A Tatsuguchi,T Kishida,S Fujimori,S Tanaka,K Gudis,S Shinji,K Furukawa,T Tajiri,Y Sugisaki,Y Fukuda,C Sakamoto,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Alimentary pharmacology & therapeutics

VOLUME: 24 Suppl 4

Page Numbers: 153-9

Journal Abbreviation: Aliment. Pharmacol. Ther.

ISSN: 0269-2813

DAY: 9

MONTH: Dec

YEAR: 2006

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8707234

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue.

AFFILIATION: Third Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Aliment Pharmacol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue Related Publications

• A case of cholangiocarcinoma mimicking inflammatory pseudotumor.
• A randomized phase II selection trial in patients with advanced/recurrent gastric cancer: Trial for Advanced Stomach Cancer (TASC).
• Association between reflux esophagitis and/or hiatus hernia and gastric mucosal atrophy level in Japan.
• Autoimmune urticaria at 3 years of age diagnosed by puncture skin test using autologous serum.
• Carbohydrate tumor marker: basis for a simple test for colorectal cancer.
• Chemopreventive effect of a vitamin D(3) analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis.
• Clock gene expression in the rat retina: effects of lighting conditions and photoreceptor degeneration.
• Conformational behavior of N-acylamino acid oil and N-acylamino acid surfactant in aqueous solution.
• Conjunctival nodules associated with Vogt-Koyanagi-Harada disease.
• Current status of double balloon endoscopy--indications, insertion route, sedation, complications, technical matters.
• Diagnosis and treatment of obscure gastrointestinal bleeding using combined capsule endoscopy and double balloon endoscopy: 1-year follow-up study.
• Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue.
• Early destructive lesions in the developing brain: clinical and electrographic correlates.
• Efficacy of adjuvant chemotherapy using oral fluorinated pyrimidines for curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials in Japan.
• Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization.
• Helicobacter pylori infection induces accumulation of Vdelta1 T cells via CCR2 upregulation.
• Incessant non-sustained ventricular tachycardia after stimulus of electroconvulsive therapy with atropine premedication?
• Inflation of the distal cuff by saline reduces the incidence of malposition of the bronchial tube during lung separation in patients receiving nitrous oxide.
• Iron chelators may help prevent photoaging.
• Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion.
• Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
• Mechanisms of Acid gastroesophageal reflux in the Japanese population.
• Morphological characteristics of lateral pelvic lymph nodes in rectal carcinoma.
• Pathology of early hepatocellular carcinoma.
• Spawning of the Kissing Loach (Leptobotia curta) is Limited to Periods Following the Formation of Temporary Waters.
• The RNAi-mediated silencing of xanthine dehydrogenase impairs growth and fertility and accelerates leaf senescence in transgenic Arabidopsis plants.
• The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review.
• [Anesthesia management for laparoscopic prostatectomy and open prostatectomy]
• [Risk factors and comorbidities for NSAID associated ulcer]
• [The choice of selective COX-2 inhibitors]