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Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.

Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Research Abstract Details 

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  • Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Abstract Text:

    ge-hong sun-wadaGe-Hong Sun-Wada,hiroyuki tabataHiroyuki Tabata,nobuyuki kawamuraNobuyuki Kawamura,masamitsu futaiMasamitsu Futai,yoh wadaYoh Wada,ge-hong sun-wadaGe-Hong Sun-Wada,hiroyuki tabataHiroyuki Tabata,nobuyuki kawamuraNobuyuki Kawamura,masamitsu futaiMasamitsu Futai,yoh wadaYoh Wada,

    Vacuolar-type proton ATPase (V-ATPase) is a multi-subunit enzyme that couples ATP hydrolysis to the translocation of protons across membranes. Mammalian cells express four isoforms of the a subunit of V-ATPase. Previously, we have shown that V-ATPase with the a3 isoform is highly expressed in pancreatic islets and is located in the membranes of insulin-containing granules in the beta cells. The a3 isoform functions in the regulation of hormone secretion. In this study, we have examined the distribution of a subunit isoforms in endocrine tissues, including the adrenal, parathyroid, thyroid, and pituitary glands, with isoform-specific antibodies. We have found that the a3 isoform is strongly expressed in all these endocrine tissues. Our results suggest that functions of the a3 isoform are commonly involved in the process of exocytosis in regulated secretion.

    Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Publishing Authors By Initials

    gh sun-wadaGH Sun-Wada,h tabataH Tabata,n kawamuraN Kawamura,m futaiM Futai,y wadaY Wada,gh sun-wadaGH Sun-Wada,h tabataH Tabata,n kawamuraN Kawamura,m futaiM Futai,y wadaY Wada,

    For similar abstracts research abstracts see: abstracts research

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    Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Cell and tissue research

    VOLUME: 329

    Page Numbers: 239-48

    Journal Abbreviation: Cell Tissue Res.

    ISSN: 0302-766X

    DAY: 12

    MONTH: 05

    YEAR: 2007

    Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Information

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    LANGUAGE: eng

    NlmUniqueID: 417625

    Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues. Keywords Mesh Terms:

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    Grant and Affiliation Information for Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues.

    AFFILIATION: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College, Kyotanabe, 610-0395, Japan. kwada@dwc.doshisha.ac.jp

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    MEDLINETA: Cell Tissue Res

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