Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin.

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Abstract Text:

Laure ,Sanjay Kansra,Stefan W Stoll,Yong Li,Johann E Gudjonsson,Yuan Shao,Lowell E Michael,Gary J Fisher,Timothy M Johnson,James T Elder,

In this study, we examined ErbB1 signaling in human basal and squamous cell carcinomas (BCC and SCC) of the skin in vivo. We used enzyme-linked immunosorbent assay, laser capture microdissection-coupled real-time reverse transcriptase-polymerase chain reaction, and immunohistochemistry to assess expression and activation levels of ErbB1 protein, ligands, and potential downstream effectors, in BCC and SCC tumors, stroma, and adjacent epidermis. Although total ErbB1 protein and mRNA were similar in cancerous and normal skin, we found that ErbB1 activation (phospho-Tyr(1068)) was greater in bulk SCC versus BCC or normal skin. In addition, three ErbB1 ligand transcripts (amphiregulin, heparin-binding epidermal growth factor-like growth factor, and transforming growth factor-alpha) were up-regulated in tumor cells of SCC but not BCC. Expression of these ligands was also increased in asymptomatic epidermis adjacent to both SCC and BCC, relative to normal skin. Interestingly, betacellulin transcript levels were inversely regulated compared with the other ligands. Consistently, downstream ErbB1 effectors (Erk1/2 and Akt) were activated in tumor cells of SCC but not of BCC and in adjacent epidermis of both BCC and SCC. These results demonstrate that ErbB1 signaling is hyperactive in tumor cells of SCC but not of BCC and in nearby asymptomatic epidermis of both tumor types. Our results suggest that targeting ErbB1 signaling might be of benefit in the treatment of SCC.

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Publishing Authors By Initials

L ,S Kansra,SW Stoll,Y Li,JE Gudjonsson,Y Shao,LE Michael,GJ Fisher,TM Johnson,JT Elder,

For similar peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research abstracts see: peptides: intercellular signaling peptides and proteins: transforming growth factors: transforming growth factor alpha research

PUBMED ID PMID:

MEDLINE DATE:

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of pathology

VOLUME: 170

Page Numbers: 2089-99

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 3

MONTH: Jun

YEAR: 2007

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin.

AFFILIATION: Department of Dermatology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0932, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: T32 AR 07197

ACRONYM: AR

MEDLINETA: Am J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin Related Publications

• A physiological replacement for polyvinylpyrrolidone (PVP) in assisted reproductive technology.
• Actin and flagellin may have an N-terminal relationship.
• Almost 9: a personal essay on parenting, aniridia, and being a doctor.
• Association between family variables and Mexican American children's dietary behaviors.
• Automatic determination of ligand purity and apparent dissociation constant (K(app)) in Ca(2+)/Mg(2+) buffer solutions and the K(app) for Ca(2+)/Mg(2+) anion binding in physiological solutions from Ca(2+)/Mg(2+)-macroelectrode measurements.
• Breastfeeding videos offer reliable information and vivid images.
• Cold agglutinins and other tests for atypical pneumonia.
• Coördinating Committee on Laboratory Methods.
• Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin.
• Emission energy correlates with inverse of gold-gold distance for various [Au(SCN)2]- salts.
• Family medicine and the life course paradigm.
• Girls' activity levels and lesson contexts in middle school PE: TAAG baseline.
• Interpretation of anogenital findings in the living child: Implications for the paediatric forensic autopsy.
• Intervention Protocol: 361: 1:30 PM-1:45 PM.
• Management of congenital elevation deficiency due to congenital third nerve palsy and monocular elevation deficiency.
• Medical treatment of cataract.
• Mouse models of psoriasis.
• Pepsin pretreatment allows collagen IV immunostaining of blood vessels in adult mouse brain.
• Psoriasis: epidemiology.
• Quantum chemical determination of Young's modulus of lignin. Calculations on a beta-O-4' model compound.
• Race-ethnic inequality and psychological distress: depressive symptoms from adolescence to young adulthood.
• Racial self-categorization in adolescence: multiracial development and social pathways.
• Some problems in the physiology of the eye.
• Some problems in the physiology of the eye.
• Sun sensitivity in 5 US ethnoracial groups.
• The health trade-off of rural residence for impaired older adults: longer life, more impairment.
• The predominance of counterclockwise rotation during swarming of bacillus species.
• The public health nurse in Northern Ireland.
• The relation of acculturation to latinas' perceived neighborhood safety and physical activity: a structural equation analysis.
• You Can Beat the A-Bomb.