Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem.

Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Research Abstract Details 

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Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Abstract Text:

Lisa L Ji,Helmut B Gottlieb,Maurice L Penny,Tiffany Fleming,Glenn M Toney,J Thomas Cunningham,

This study examined the effects of dehydration and rehydration with water on Fos and FosB staining in the brainstem of rats. Male rats were water deprived for 48 h (Dehyd, n=7) or 46 h followed by 2 h access to water (Rehyd, n=7). Controls had ad libitum access to water (Con, n=9). Brainstems were stained for Fos and FosB/DeltaFosB using commercially available antibodies. In the nucleus of the solitary tract (NTS), the number of Fos stained neurons was significantly increased by dehydration and increased further following rehydration (Con 5+/-1; Dehyd 22+/-1; Rehyd 48+/-5). The average number of Fos-positive cells in the parabrachial nucleus (PBN) was significantly increased only by rehydration (Con 12+/-2; Dehyd 6+/-2; Rehyd 51+/-4). The area postrema (AP) showed significant increases in Fos staining after dehydration and rehydration (Fos: Con 4+/-1; Dehyd 28+/-3; Rehyd 24+/-3). In the rostral ventrolateral medulla (RVL), Fos staining significantly increased after dehydration and this effect was reduced by rehydration (Con 3+/-1; Dehyd 21+/-2; Rehyd 12+/-1). In contrast, Fos staining in the caudal ventrolateral medulla (CVL) was not significantly influenced following either dehydration or rehydration with water (Con 4+/-1; Dehyd 4+/-1; Rehyd 5+/-1). FosB/DeltaFosB staining in the NTS, AP, and RVL was comparably increased by dehydration and rehydration. In the PBN and CVL, FosB/DeltaFosB staining was not affected by the treatments. Dehydration and rehydration have regionally specific effects on Fos and FosB/DeltaFosB staining in the brainstem.

Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Publishing Authors By Initials

LL Ji,HB Gottlieb,ML Penny,T Fleming,GM Toney,JT Cunningham,

For similar behavior and behavior mechanisms: motivation: water deprivation research abstracts see: behavior and behavior mechanisms: motivation: water deprivation research

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Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Experimental neurology

VOLUME: 203

Page Numbers: 445-56

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 6

MONTH: 10

YEAR: 2006

Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370712

Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Keywords Mesh Terms:

KEYWORDS: Water Deprivation

MESH TERMS: physiology

Chemical & Substance for Abstract: Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem. Information

Substance Name: Dopamine beta-Hydroxylase

Registry Number: EC 1.14.17.1

Grant and Affiliation Information for Differential effects of water deprivation and rehydration on Fos and FosB/DeltaFosB staining in the rat brainstem.

AFFILIATION: Department of Pharmacology, and the Center for Biomedical Neuroscience, UTHSCSA, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL62570

ACRONYM: HL

MEDLINETA: Exp Neurol

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