Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes.

Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. Research Abstract Details 

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Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. Abstract Text:

Riad M Rahhal,Tony J Vanden Bush,Molly K McLendon,Michael A Apicella,Gail A Bishop,Riad M Rahhal,Tony J Vanden Bush,Molly K McLendon,Michael A Apicella,Gail A Bishop,

Francisella tularensis, a designated Category A biological agent, can cause severe infection in humans. Previous studies have demonstrated a significant immunoprotective role for B lymphocytes in animal models, but the responses of human B lymphocytes to F. tularensis components are largely unknown. The LPS of F. tularensis is atypical and has been reported to lack biological activity on myeloid cells and mouse B cells. Our study characterized the immunological effects of highly purified LPS from different stains of F. tularensis on human B lymphocytes and compared these effects with those on mouse B cells and human monocyte-derived macrophages. Results indicate that marked differences exist between cell type and species in specific responses to this interesting bacterial component. In sharp contrast to responses of mouse splenic B cells or human macrophages, human peripheral B cells showed reproducibly elevated IL-6, TNF-alpha, and antibody production in response to F. tularensis LPS. Data also indicated that these activated human B lymphocytes may subsequently promote the activation of other immune cell types by direct cell-cell interaction. Further investigation into the potential usefulness of F. tularensis LPS as an adjuvant component of a more optimal subunit vaccine is warranted, as it is now clear that it is not biologically inactive, as assumed previously.

Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. Publishing Authors By Initials

RM Rahhal,TJ Vanden Bush,MK McLendon,MA Apicella,GA Bishop,RM Rahhal,TJ Vanden Bush,MK McLendon,MA Apicella,GA Bishop,

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Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 813-20

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 18

MONTH: 07

YEAR: 2007

Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes. Information

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LANGUAGE: eng

NlmUniqueID: 8405628

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Grant and Affiliation Information for Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes.

AFFILIATION: Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA099997

ACRONYM: CA

MEDLINETA: J Leukoc Biol

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