Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes.

Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Research Abstract Details 

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Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Abstract Text:

Jingxia Li,Dongyun Zhang,Gary D Stoner,Chuanshu Huang,

The chemopreventive properties of edible berries have been demonstrated both in vitro and in vivo, however, the specific molecular mechanisms underlying their anti-cancer effects are largely unknown. Our previous studies have shown that a methanol extract fraction of freeze-dried black raspberries inhibits benzoapyrene (BaP)-induced transformation of Syrian hamster embryo cells. This fraction also blocks activation of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB) induced by benzoapyrene diol-epoxide (BaPDE) in mouse epidermal JB6 Cl 41 cells. To determine if different berry types exhibit specific mechanisms for their anti-cancer effects, we compared the effects of extract fractions from both black raspberries and strawberries on BaPDE-induced activation of various signaling pathways in Cl 41 cells. Black raspberry fractions inhibited the activation of AP-1, NF-kappaB, and nuclear factor of activated T cells (NFAT) by BaPDE as well as their upstream PI-3K/Akt-p70(S6K) and mitogen-activated protein kinase pathways. In contrast, strawberry fractions inhibited NFAT activation, but did not inhibit the activation of AP-1, NF-kappaB or the PI-3K/Akt-p70(S6K) and mitogen-activated protein kinase pathways. Consistent with the effects on NFAT activation, tumor necrosis factor-alpha (TNF-alpha) induction by BaPDE was blocked by extract fractions of both black raspberries and strawberries, whereas vascular endothelial growth factor (VEGF) expression, which depends on AP-1 activation, was suppressed by black raspberry fractions but not strawberry fractions. These results suggest that black raspberry and strawberry components may target different signaling pathways in exerting their anti-carcinogenic effects.

Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Publishing Authors By Initials

J Li,D Zhang,GD Stoner,C Huang,

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Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular carcinogenesis

VOLUME: 47

Page Numbers: 286-94

Journal Abbreviation: Mol. Carcinog.

ISSN: 1098-2744

DAY: 13

MONTH: Apr

YEAR: 2008

Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Information

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LANGUAGE: eng

NlmUniqueID: 8811105

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Grant and Affiliation Information for Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes.

AFFILIATION: Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES012451

ACRONYM: ES

MEDLINETA: Mol Carcinog

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