Differential cellular expression of LIGHT and its receptors in early gestation human placentas.

Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Research Abstract Details 

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Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Abstract Text:

Ryan M Gill,Neil M Coleman,Joan S Hunt,

LIGHT (homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed by T lymphocytes) is an apoptosis-inducing member of the tumor necrosis factor family of ligands. Messenger RNAs encoding LIGHT and its receptors, lymphotoxin-beta receptor (LTbetaR), decoy receptor-3 (DcR3) and herpes virus entry mediator (HVEM), are present in first trimester and term placentas. Proteins have been localized to specific cells in term but not earlier gestation placentas. Here, we have studied LIGHT and its receptors in early (6-7 weeks) and early-to-middle (8-13 weeks) gestation using immunohistology. Notable cell-specific, gestation-related features were identified. LIGHT and two of its receptors, a membrane-bound receptor that mediates apoptosis (LTbetaR) and a soluble receptor that interferes with LIGHT signaling (DcR3), were present in syncytiotrophoblast and cytotrophoblast cells in all samples but were detected in placental stromal cells only at week 8 and thereafter. HVEM, a membrane-bound receptor that protects against apoptosis, was expressed only on syncytiotrophoblast. These observations suggest that the LIGHT system may regulate early to middle stages of placental development via cell-specific, temporally programmed expression of the ligand and its receptors, and may also assist in preserving placental immune privilege.

Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Publishing Authors By Initials

RM Gill,NM Coleman,JS Hunt,

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Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of reproductive immunology

VOLUME: 74

Page Numbers: 1-6

Journal Abbreviation: J. Reprod. Immunol.

ISSN: 0165-0378

DAY: 27

MONTH: 09

YEAR: 2006

Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Information

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LANGUAGE: eng

NlmUniqueID: 8001906

Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor Ligand Superfamily

MESH TERMS: metabolism

Chemical & Substance for Abstract: Differential cellular expression of LIGHT and its receptors in early gestation human placentas. Information

Substance Name: Tumor Necrosis Factor Ligand Superfamily

Registry Number: 0

Grant and Affiliation Information for Differential cellular expression of LIGHT and its receptors in early gestation human placentas.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. ryanmgill@gmail.com

Country: Ireland

AGENCY: United States NICHD

GRANT: HD33994

ACRONYM: HD

MEDLINETA: J Reprod Immunol

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