Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland.

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Abstract Text:

S Takekida,L Yan,E S Maywood,M H Hastings,H Okamura,

Precise temporal regulation of transcription is pivotal to the role of the mammalian pineal gland as a transducer of circadian and seasonal information. The circadian clock genes Per1 and Per2 encode factors implicated in temporally gated transcriptional programmes in brain and pituitary. Here we show that the nocturnal circadian expression of Per1 and Per2 in the rat pineal gland parallels that of serotonin N-acetyltransferase (NAT) mRNA, which encodes the rate-limiting enzyme of melatonin biosynthesis. This rhythm is dependent upon an intact sympathetic innervation. Increases in rPer1 (r indicates rat) and rPer2, as well as rNAT, expression during subjective night were blocked completely by superior cervical ganglionectomy (SCGX). In SCGX rats, the beta-adrenergic receptor agonist isoproterenol rapidly induced the rPer1 mRNA with dynamics very similar to its effect on rNAT mRNA. In contrast, isoproterenol was without effect on expression of rPer2 mRNA. These findings demonstrate that circadian pineal expression of both rPer1 and rPer2 is controlled by sympathetic afferent innervation, but whereas beta-adrenergic signalling regulates rPer1 and rNAT, an alternative route mediates sympathetic regulation over rPer2 expression.

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Publishing Authors By Initials

S Takekida,L Yan,ES Maywood,MH Hastings,H Okamura,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

MEDLINE DATE:

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 12

Page Numbers: 4557-61

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 19

MONTH: Dec

YEAR: 2000

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland. Information

Substance Name: Arylamine N-Acetyltransferase

Registry Number: EC 2.3.1.5

Grant and Affiliation Information for Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland.

AFFILIATION: Department of Anatomy and Brain Science, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Country: FRANCE

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland Related Publications

• A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus.
• Additional evidence for the semiquinoid-FAD in d-aminoacid oxidase Michaelis complex crystal.
• Control mechanism of the circadian clock for timing of cell division in vivo.
• Depolarization activates the phosphoinositide phosphatase Ci-VSP, as detected in Xenopus oocytes coexpressing sensors of PIP2.
• Differential adrenergic regulation of the circadian expression of the clock genes Period1 and Period2 in the rat pineal gland.
• Dimerization and nuclear entry of mPER proteins in mammalian cells.
• Does mPER2 protein oscillate without its coding mRNA cycling?: post-transcriptional regulation by cell clock.
• Dynamic augmented reality for sensory substitution in robot-assisted surgical systems.
• ENDOR spectroscopy reveals light induced movement of the H-bond from Ser-L223 upon forming the semiquinone (Q(B)(-)(*)) in reaction centers from Rhodobacter sphaeroides.
• Endoparasitism in colonial hosts: patterns and processes.
• Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.
• Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts.
• Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus.
• Involvement of Interleukin 18 in Cataract Development in Hereditary Cataract UPL Rats.
• Molecular analysis of Clostridium difficile at a university teaching hospital in Japan: a shift in the predominant type over a five-year period.
• Molecular mechanisms of the biological clock in cultured fibroblasts.
• Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
• Occurrence of two intermediates in D-amino acid oxidase reaction.
• Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light.
• Phase-dependent responses of Per1 and Per2 genes to a light-stimulus in the suprachiasmatic nucleus of the rat.
• Primary Ewing's sarcoma family tumors of the lung a case report and review of the literature.
• Reaction of D-amino acid oxidase with D-lysine.
• Replication of deoxyribonucleic acid in Escherichia coli under limited supply of oxygen.
• Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2.
• Revised culture-based system for identification of Malassezia species.
• Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.
• Role of cyclic mPer2 expression in the mammalian cellular clock.
• Sloughing off of a cervical myoma after cesarean section: a case report.
• Synchronization of cellular clocks in the suprachiasmatic nucleus.
• [Effect of mental fatigue induced by repeated continuous calculation tasks on event-related brain potential (P300)]