Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach.

Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach. Research Abstract Details 

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Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach. Abstract Text:

Stefano Salvioli,Miriam Capri,Paolo Tieri,Jonathan Loroni,Cristiana Barbi,Laura Invidia,Serena Altilia,Aurelia Santoro,Chiara Pirazzini,Michela Pierini,Elena Bellavista,Lilia Alberghina,Claudio Franceschi,

Cell death is as important as cell proliferation for cell turn-over, and susceptibility to cell death is affected by a number of parameters that change with time. A time-dependent derangement of such a crucial process, or even the simple cell loss mediated by cell death impinges upon aging and longevity. In this review we will discuss how cell death phenomena are modulated during aging and what is their possible role in the aging process. We will focus on apoptosis and autophagy, which affect mostly proliferating and post-mitotic cells, respectively, and on mitochondrial degradation in long living cells. Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach.

Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach. Publishing Authors By Initials

S Salvioli,M Capri,P Tieri,J Loroni,C Barbi,L Invidia,S Altilia,A Santoro,C Pirazzini,M Pierini,E Bellavista,L Alberghina,C Franceschi,

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Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current pharmaceutical design

VOLUME: 14

Page Numbers: 226-36

Journal Abbreviation: Curr. Pharm. Des.

ISSN: 1873-4286

DAY: 28

MONTH: 01

YEAR: 2008

Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach. Information

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LANGUAGE: eng

NlmUniqueID: 9602487

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Grant and Affiliation Information for Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach.

AFFILIATION: Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna, Italy.

Country: Netherlands

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MEDLINETA: Curr Pharm Des

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