Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization.

Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization. Research Abstract Details 

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Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization. Abstract Text:

Ryuichi Noguchi,Hitoshi Yoshiji,Yasuhide Ikenaka,Mitsuteru Kitade,Kosuke Kaji,Junichi Yoshi,Koji Yanase,Tadashi Namisaki,Masaharu Yamazaki,Tatsuhiro Tsujimoto,Takemi Akahane,Masahito Uemura,Hiroshi Fukui,Ryuichi Noguchi,Hitoshi Yoshiji,Yasuhide Ikenaka,Mitsuteru Kitade,Kosuke Kaji,Junichi Yoshi,Koji Yanase,Tadashi Namisaki,Masaharu Yamazaki,Tatsuhiro Tsujimoto,Takemi Akahane,Masahito Uemura,Hiroshi Fukui,

Interferon (IFN) is known as a multifunctional cytokine. The aim of this study was to examine the different effects of IFN subclass; namely, IFN-alpha and IFN-beta, on hepatocellular carcinoma (HCC) growth especially in conjunction with angiogenesis that is known to play a pivotal role in the tumor growth. Furthermore, we also examined whether the p53 status in the tumor would alter the anti-tumoral effect of IFN against HCC growth since the p53 status reportedly affected the therapeutic effect of anti-angiogenic agents against cancer. When compared with IFN-alpha, IFN-beta exerted a more potent inhibitory effect on HCC growth, even after the tumor was established, along with suppression of neovascularization in the tumor. A single treatment with clinically comparable low doses of IFN-beta significantly inhibited HCC growth whereas the same dose of IFN-alpha did not. IFN-beta also significantly suppressed the tumor growth both in the p53-wild and p53-mutant HCC cells. Our in vitro study revealed that IFN-beta showed a more potent inhibitory effect on the endothelial cell proliferation than IFN-alpha as in the in vivo study. Collectively, IFN may be an alternative anti-angiogenic agent against HCC since it exerted a significant tumoricidal effect regardless of the host p53 status even at a low dose. A cautious approach may be also required in the clinical practice since even in a same IFN subclass (class-I), IFN-alpha and IFN-beta exert tumoricidal effects of different magnitudes on HCC.

Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization. Publishing Authors By Initials

R Noguchi,H Yoshiji,Y Ikenaka,M Kitade,K Kaji,J Yoshi,K Yanase,T Namisaki,M Yamazaki,T Tsujimoto,T Akahane,M Uemura,H Fukui,R Noguchi,H Yoshiji,Y Ikenaka,M Kitade,K Kaji,J Yoshi,K Yanase,T Namisaki,M Yamazaki,T Tsujimoto,T Akahane,M Uemura,H Fukui,

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Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oncology

VOLUME: 32

Page Numbers: 193-9

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 21

MONTH: Jan

YEAR: 2008

Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization. Information

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LANGUAGE: eng

NlmUniqueID: 9306042

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Grant and Affiliation Information for Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization.

AFFILIATION: Third Department of Internal Medicine, Nara Medical University, Nara, Japan.

Country: Greece

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MEDLINETA: Int J Oncol

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