Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners.

Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Research Abstract Details 

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Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Abstract Text:

Zorana S Orescanin,Slobodan R Milovanovi?,Snezana D Spasi?,David R Jones,Mihajlo B Spasi?,Zorana S Orescanin,Slobodan R Milovanovi?,Snezana D Spasi?,David R Jones,Mihajlo B Spasi?,

The conversion of nitric oxide (NO*) into its congeners nitrosonium (NO(+)) and nitroxyl (HNO/NO(-)) ions may have important consequences for signal transduction and physiological responses. Manganese-containing superoxide dismutase (MnSOD) may convert NO. into its redox congeners. In our current work, we have examined the mechanism of sodium nitroprusside (SNP)-induced relaxation of arteries, with or without endothelium, from both normotensive and spontaneously hypertensive (SH) rats in the absence and presence of MnSOD. SNP induced a greater degree of relaxation in normotensive than in SH rats. MnSOD antagonized SNP-induced relaxation and effect was greater in normotensive than hypertensive rats. However, MnSOD even potentiated SNP-induced relaxation in mesenteric arteries with endothelium from SH rats. Our results indicate that HNO/NO(-)-mediated relaxation is more effective in mesenteric artery smooth muscle from SH rats than from normotensive rats and that vascular dysfunction in SH rats is not solely endothelium-derived but involves changes in vascular smooth muscles.

Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Publishing Authors By Initials

ZS Orescanin,SR Milovanovi?,SD Spasi?,DR Jones,MB Spasi?,ZS Orescanin,SR Milovanovi?,SD Spasi?,DR Jones,MB Spasi?,

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PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pharmacological reports : PR

VOLUME: 59

Page Numbers: 315-22

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ISSN: 1734-1140

DAY: 26

MONTH: 07

YEAR: 2007

Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners. Information

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LANGUAGE: eng

NlmUniqueID: 101234999

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Grant and Affiliation Information for Different responses of mesenteric artery from normotensive and spontaneously hypertensive rats to nitric oxide and its redox congeners.

AFFILIATION: Department of Physiology, Institute for Biological Research Sinisa Stankovi?, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

Country: Poland

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MEDLINETA: Pharmacol Rep

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