Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum.

Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Research Abstract Details 

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Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Abstract Text:

Susan S Suarez,Becky Marquez,Tanya P Harris,John C Schimenti,

In mammalian sperm, the flagellar midpiece and principal piece contain different signalling molecules and ion channels. For example, the soluble adenylyl cyclase (sAC), which is required for activation of motility, is restricted to the midpiece, while the plasma membrane calcium channels CatSper1 and CatSper2, which are required for hyperactivation of motility, are restricted to the principal piece. The midpiece and principal piece are partially separated by a barrier called the annulus, yet despite this and the differential distribution of signalling molecules, they normally appear to work together to produce a wave that propagates smoothly down the tail. Under certain circumstances, however, the two segments can act independently. This is the case for sperm of Ste5Jcs l mutant mice, which swim with stiff midpieces but vigorously-beating principal pieces, due apparently to a defect in the mitochondria.

Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Publishing Authors By Initials

SS Suarez,B Marquez,TP Harris,JC Schimenti,

For similar urogenital system: genitalia: germ cells: spermatozoa: sperm tail research abstracts see: urogenital system: genitalia: germ cells: spermatozoa: sperm tail research

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Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Journal Published:

PUBLICATION TYPE: Review

Journal: Society of Reproduction and Fertility supplement

VOLUME: 65

Page Numbers: 331-4

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ISSN:

DAY: 19

MONTH: 11

YEAR: 2007

Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Information

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LANGUAGE: eng

NlmUniqueID: 101295315

Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Keywords Mesh Terms:

KEYWORDS: Sperm Tail

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Information

Substance Name: Ion Channels

Registry Number: 0

Grant and Affiliation Information for Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum.

AFFILIATION: Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA. sss7@cornell.edu

Country: England

AGENCY: United States NICHD

GRANT: HD35984

ACRONYM: HD

MEDLINETA: Soc Reprod Fertil Suppl

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