Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Abstract Text:

An-Tao Du,Norbert Schuff,Joel H Kramer,Howard J Rosen,Maria Luisa Gorno-Tempini,Katherine Rankin,Bruce L Miller,Michael W Weiner,

Alzheimer's disease and frontotemporal dementia (FTD) can be difficult to differentiate clinically because of overlapping symptoms. Distinguishing the two dementias based on volumetric measurements of brain atrophy with MRI has been only partially successful. Whether MRI measurements of cortical thinning improve the differentiation between Alzheimer's disease and FTD is unclear. In this study, we measured cortical thickness using a set of automated tools (Freesurfer) to reconstruct the brain's cortical surface from T1-weighted structural MRI data in 22 patients with Alzheimer's disease, 19 patients with FTD and 23 cognitively normal subjects. The goals were to detect the characteristic patterns of cortical thinning in these two types of dementia, to test the relationship between cortical thickness and cognitive impairment, to determine if measurement of cortical thickness is better than that of cortical volume for differentiating between these dementias and normal ageing and improving the classification of Alzheimer's disease and FTD based on neuropsychological scores alone. Compared to cognitively normal subjects, Alzheimer's disease patients had a thinner cortex primarily in bilateral, frontal, parietal, temporal and occipital lobes (P < 0.001), while FTD patients had a thinner cortex in bilateral, frontal and temporal regions and some thinning in inferior parietal regions and the posterior cingulate (P < 0.001). Compared to FTD patients, Alzheimer's disease patients had a thinner cortex (P < 0.001) in parts of bilateral parietal and precuneus regions. Cognitive impairment was negatively correlated with cortical thickness of frontal, parietal and temporal lobes in Alzheimer's disease, while similar correlations were not significant in FTD. Measurement of cortical thickness was similar to that of cortical volume in differentiating between normal ageing, Alzheimer's disease and FTD. Furthermore, cortical thickness measurements significantly improved the classification between Alzheimer's disease and FTD based on neuropsychological scores alone, including the Mini-Mental State Examination and a modified version of the Trail-Making Test. In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia.

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Publishing Authors By Initials

AT Du,N Schuff,JH Kramer,HJ Rosen,ML Gorno-Tempini,K Rankin,BL Miller,MW Weiner,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: temporal lobe research

PUBMED ID PMID:

MEDLINE DATE:

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Brain : a journal of neurology

VOLUME: 130

Page Numbers: 1159-66

Journal Abbreviation:

ISSN: 1460-2156

DAY: 12

MONTH: 03

YEAR: 2007

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372537

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Keywords Mesh Terms:

KEYWORDS: Temporal Lobe

MESH TERMS: pathology

Chemical & Substance for Abstract: Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.

AFFILIATION: Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA. antao.du@ucsf.edu

Country: England

AGENCY: United States NIA

GRANT: R01 AG010897-21

ACRONYM: AG

MEDLINETA: Brain

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia Related Publications

• A randomized clinical trial comparing the effect of maternal intravenous hydration and placebo on the amniotic fluid index in oligohydramnios.
• ADCS Prevention Instrument Project: quality of life assessment (QOL).
• Adapting a dynamic model of interorganizational cooperation to the health care sector.
• Anisotropic Poisson's ratio and compression modulus of cortical bone determined by speckle interferometry.
• Bayesian parallel imaging with edge-preserving priors.
• Binding of mitochondrial leader sequences to Tom20 assessed using a bacterial two-hybrid system shows that hydrophobic interactions are essential and that some mutated leaders that do not bind Tom20 can still be imported.
• Biomechanical properties of the lower uterine segment above and below the reflection of the urinary bladder flap.
• Cardiovascular disease and subsequent kidney disease.
• Caregiving burden responses differ for Internet and telephone data collection.
• Chronic low back pain in older adults: What physicians know, what they think they know, and what they should be taught.
• Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis.
• Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner.
• Delivery of drugs and macromolecules to mitochondria.
• Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.
• Efficacy of novel plasmid DNA encoding vaccinia antigens in improving current smallpox vaccination strategy.
• Electronic health records: high-quality electronic data for higher-quality clinical research.
• Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney.
• How the parallel channels of the retina contribute to depth processing.
• Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T.
• Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphisms.
• Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays.
• Recovery preference exploration: analysis of patient feedback after imagined scenarios.
• Reengineering CCA-adding enzymes to function as (U,G)- or dCdCdA-adding enzymes or poly(C,A) and poly(U,G) polymerases.
• Regulation of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent affinity for target antigen.
• Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice.
• Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity.
• The hairless mouse ear: an in vivo model for studying wound neovascularization.
• The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b.
• Voxel-based T2 relaxation rate measurements in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis.
• X-ray absorption spectroscopic characterization of the molybdenum site of Escherichia coli dimethyl sulfoxide reductase.