[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing]

[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing] Research Abstract Details 

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[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing] Abstract Text:

Xiaobing Fu,Hui Zhang,Xialian Xu,Tongzhu Sun,Zhijie Chang,

OBJECTIVE: To explore the expression characteristics of chaperone interacting protein (CHIP) in normal, scar and chronic ulcer tissues and its relationship with wound healing. METHODS: Twenty biopsies including scar tissues (n = 8), chronic ulcer tissues (n = 4) and normal tissues (n = 8) were used in this study. The immunohistochemical staining (power vision two-step histostaining reagent) was used to explore the amount and expression characteristics of such protein. RESULTS: The positive expression of CHIP was observed in fibroblasts, endothelial cells and epidermal cells in dermis and epidermis. It was not seen in inflammatory cells. The expression amount of CHIP in scar tissues, chronic ulcer tissues and normal tissues was 89%, 83% and 17% respectively. CONCLUSION: Although the function of CHIP is not fully understood at present, the fact that this protein is expressed only at the mitogenic cells indicates that it may be involved in mitogenic regulation during wound healing.

[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing] Publishing Authors By Initials

X Fu,H Zhang,X Xu,T Sun,Z Chang,

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[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhonggu

VOLUME: 19

Page Numbers: 127-9

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ISSN: 1002-1892

DAY: 11

MONTH: Feb

YEAR: 2005

[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing] Information

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LANGUAGE: chi

NlmUniqueID: 9425194

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AFFILIATION: Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China. fuxb@cgw.net.cn

Country: China

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MEDLINETA: Zhongguo Xiu Fu Chong Jian Wai

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