Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons.

Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Research Abstract Details 

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Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Abstract Text:

Jungnam Lee,Richard Cordaux,Kyudong Han,Jianxin Wang,Dale J Hedges,Ping Liang,Mark A Batzer,

The long interspersed element-1 (LINE-1 or L1) is a highly successful retrotransposon in mammals. L1 elements have continued to actively propagate subsequent to the human-chimpanzee divergence, approximately 6 million years ago, resulting in species-specific inserts. Here, we report a detailed characterization of chimpanzee-specific L1 subfamily diversity and a comparison with their human-specific counterparts. Our results indicate that L1 elements have experienced different evolutionary fates in humans and chimpanzees within the past approximately 6 million years. Although the species-specific L1 copy numbers are on the same order in both species (1200-2000 copies), the number of retrotransposition-competent elements appears to be much higher in the human genome than in the chimpanzee genome. Also, while human L1 subfamilies belong to the same lineage, we identified two lineages of recently integrated L1 subfamilies in the chimpanzee genome. The two lineages seem to have coexisted for several million years, but only one shows evidence of expansion within the past three million years. These differential evolutionary paths may be the result of random variation, or the product of competition between L1 subfamily lineages. Our results suggest that the coexistence of several L1 subfamily lineages within a species may be resolved in a very short evolutionary period of time, perhaps in just a few million years. Therefore, the chimpanzee genome constitutes an excellent model in which to analyze the evolutionary dynamics of L1 retrotransposons.

Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Publishing Authors By Initials

J Lee,R Cordaux,K Han,J Wang,DJ Hedges,P Liang,MA Batzer,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Gene

VOLUME: 390

Page Numbers: 18-27

Journal Abbreviation: Gene

ISSN: 0378-1119

DAY: 16

MONTH: 09

YEAR: 2006

Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Information

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LANGUAGE: eng

NlmUniqueID: 7706761

Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: genetics

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Grant and Affiliation Information for Different evolutionary fates of recently integrated human and chimpanzee LINE-1 retrotransposons.

AFFILIATION: Department of Biological Sciences, Biological Computation and Visualization Center, Center for BioModular Multi-Scale Systems, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: R03 CA101515-01

ACRONYM: CA

MEDLINETA: Gene

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