Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle.

Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Research Abstract Details 

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Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Abstract Text:

Diane R Baker,Rodney A Moxley,Mike B Steele,Jeffrey T Lejeune,Jane Christopher-Hennings,Ding-Geng Chen,Philip R Hardwidge,David H Francis,Diane R Baker,Rodney A Moxley,Mike B Steele,Jeffrey T Lejeune,Jane Christopher-Hennings,Ding-Geng Chen,Philip R Hardwidge,David H Francis,Diane R Baker,Rodney A Moxley,Mike B Steele,Jeffrey T Lejeune,Jane Christopher-Hennings,Ding-Geng Chen,Philip R Hardwidge,David H Francis,

Escherichia coli O157:H7 causes life-threatening outbreaks of diarrhea, hemorrhagic colitis, and hemolytic-uremic syndrome in humans and significant economic loss in agriculture and could be a potential agent of bioterrorism. Although the prevalence of E. coli O157:H7 in cattle and other species with which humans have frequent contact is high, human infections are relatively uncommon, despite a low infectious dose. A plausible explanation for the low disease incidence is the possibility that not all strains are virulent in humans. If there are substantial differences in virulence among strains in nature, then human disease may select for high virulence. We used a gnotobiotic piglet model to investigate the virulence of isolates from healthy cattle and from humans in disease outbreaks and to determine the correlation between production of Shiga toxin 1 (Stx1) and Stx2 and virulence. Overall, E. coli O157:H7 strains isolated from healthy cattle were less virulent in gnotobiotic piglets than strains isolated from humans during disease outbreaks. The amount of Stx2 produced by E. coli O157:H7 strains correlated with strain virulence as measured by a reduction in piglet survival and signs of central nervous system disease due to brain infarction. The amount of Stx1 produced in culture was not correlated with the length of time of piglet survival or with signs of central nervous system disease. We suggest that disease outbreaks select for producers of high levels of Stx2 among E. coli O157:H7 strains shed by animals and further suggest that Stx1 expression is unlikely to be significant in human outbreaks.

Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Publishing Authors By Initials

DR Baker,RA Moxley,MB Steele,JT Lejeune,J Christopher-Hennings,DG Chen,PR Hardwidge,DH Francis,DR Baker,RA Moxley,MB Steele,JT Lejeune,J Christopher-Hennings,DG Chen,PR Hardwidge,DH Francis,DR Baker,RA Moxley,MB Steele,JT Lejeune,J Christopher-Hennings,DG Chen,PR Hardwidge,DH Francis,

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Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Applied and environmental microbiology

VOLUME: 73

Page Numbers: 7338-46

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ISSN: 0099-2240

DAY: 21

MONTH: 09

YEAR: 2007

Differences in Virulence among Escherichia coli O157:H7 Strains Isolated from Humans during Disease Outbreaks and from Healthy Cattle. Information

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LANGUAGE: eng

NlmUniqueID: 7605801

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AFFILIATION: Veterinary Science Department, South Dakota State University, Box 2175, 1119 North Campus Drive, Brookings, SD 57007. david.francis@sdstate.edu.

Country: United States

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MEDLINETA: Appl Environ Microbiol

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