Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets.

Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Research Abstract Details 

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Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Abstract Text:

Sara B Glickstein,Suzy Alexander,M Elizabeth Ross,

Regulation of neural proliferation is an essential component of brain formation and is driven by both intrinsic cell cycle and extrinsic growth and trophic molecules. Among the cell cycle proteins, understanding of the relative roles of the G1-phase active cyclins D2 and D1 (cD2 and cD1) has been hampered by lack of data regarding their expression patterns. In this study, cD2 immunoreactivity was examined in the neocortex, ganglionic eminences/striatum, and hippocampal formation from embryonic day 12.5 until postnatal day 60 to more precisely characterize the expression of this protein during forebrain development. The localization of cD1 was also immunohistologically mapped for comparison. Throughout forebrain development, both overlapping and nonoverlapping protein expression of these cyclins suggests the presence of shared and unique cell cycle requirements for neurogenesis that distinguishes progenitor pools.

Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Publishing Authors By Initials

SB Glickstein,S Alexander,ME Ross,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cerebral cortex (New York, N.Y. : 1991)

VOLUME: 17

Page Numbers: 632-42

Journal Abbreviation: Cereb. Cortex

ISSN: 1047-3211

DAY: 20

MONTH: 04

YEAR: 2006

Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Information

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LANGUAGE: eng

NlmUniqueID: 9110718

Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Information

Substance Name: cyclin D

Registry Number: 0

Grant and Affiliation Information for Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets.

AFFILIATION: Laboratory of Neurogenetics and Development, Weill Medical College of Cornell University, New York, NY 10021, USA.

Country: United States

AGENCY: United States NINDS

GRANT: P01 NS048120

ACRONYM: NS

MEDLINETA: Cereb Cortex

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