Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones.

Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones. Research Abstract Details 

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Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones. Abstract Text:

Zhen-Hai Zhang,Shuo-Dong Wu,Yang Su,Jun-Zhe Jin,Ying Fan,Hong Yu,Li-Kui Zhang,Zhen-Hai Zhang,Shuo-Dong Wu,Yang Su,Jun-Zhe Jin,Ying Fan,Hong Yu,Li-Kui Zhang,

BACKGROUND: The disorders of gallbladder motility may play an important role in the formation of gallstones. Many neural and hormonal factors and their interactions regulate gallbladder motility and bile flow into the duodenum. Further study in these factors may help to reveal the etiology of gallbladder diseases. This study was undertaken to assess the relationship of the levels of motilin, vasoactive intestinal peptide (VIP) and gastrin in blood and gallbladder tissues with the formation of cholelithiasis. METHODS: The levels of motilin, gastrin and VIP in blood and gallbladder tissues of 36 patients with gallbladder stones, 14 patients with gallbladder polyps, 10 healthy volunteers and 10 patients with common bile duct stones were measured by radioimmunoassay. RESULTS: The level of motilin in plasma and gallbladder tissues of the gallbladder stone group was higher than that of the control and gallbladder polyp groups (P<0.05). The levels of plasma VIP and serum gastrin were much higher than those of the other three groups (P<0.01). The level of VIP in gallbladder tissues was higher than that of the control and gallbladder polyp groups (P<0.01). CONCLUSIONS: The abnormal excretion of hormonal factors is closely related to gallstone formation. The high level of VIP in gallbladder tissues may be an important cause of gallbladder hypomotility. The abnormal level of serum gastrin may be related to the gastrointestinal symptoms of patients with gallstones.

Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones. Publishing Authors By Initials

ZH Zhang,SD Wu,Y Su,JZ Jin,Y Fan,H Yu,LK Zhang,ZH Zhang,SD Wu,Y Su,JZ Jin,Y Fan,H Yu,LK Zhang,

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Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatobiliary & pancreatic diseases international

VOLUME: 7

Page Numbers: 58-64

Journal Abbreviation: HBPD INT

ISSN: 1499-3872

DAY: 31

MONTH: Feb

YEAR: 2008

Differences and significance of motilin, vasoactive intestinal peptide and gastrin in blood and gallbladder tissues of patients with gallstones. Information

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LANGUAGE: eng

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AFFILIATION: Department of Hepatobiliary Surgery, Shandong Provincial Hospital, Jinan 250021, China. zhangzhenhai410@yahoo.com.cn.

Country: China

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MEDLINETA: Hepatobiliary Pancreat Dis Int

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