Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination.

Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Research Abstract Details 

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Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Abstract Text:

Motoshige Yasuike,Hidehiro Kondo,Ikuo Hirono,Takashi Aoki,

The glycoprotein (G protein) gene, but not other genes, of fish rhabdoviruses, when used as a DNA vaccine was previously shown to be highly effective in inducing a protective immune response. In this study we used a DNA microarray to examine differential gene expression in Japanese flounder (Paralichthys olivaceus) in response to a DNA vaccine made from the genes of hirame rhabdovirus (Rhabdovirus olivaceus) (HIRRV) G protein (pHRV-G) and nucleocapsid (N) protein (pHRV-N). A high level of protection against HIRRV infection was observed following vaccination with the pHRV-G but no protection was observed following vaccination with the pHRV-N. Microarray analyses showed that the set of genes induced by pHRV-G was different from the set induced by pHRV-N. Specifically, five genes (Interferon-stimulated gene, 15kDa (ISG15), Interferon-stimulated gene, 56kDa (ISG56), Mx and two unknown genes) were strongly induced after injection by the pHRV-G but not pHRV-N and three of these genes are known as type I IFN-inducible genes. Poly I:C, a known inducer of type I interferon that elicits immune response similar to that elicited by a virus infection, also induced these five genes in kidney cells. These results suggest that in order to be effective and confer protection, vaccines against HIRRV and probably fish rhabdoviruses may need to stimulate the type I IFN system.

Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Publishing Authors By Initials

M Yasuike,H Kondo,I Hirono,T Aoki,

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Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Fish & shellfish immunology

VOLUME: 23

Page Numbers: 531-41

Journal Abbreviation: Fish Shellfish Immunol.

ISSN: 1050-4648

DAY: 20

MONTH: 12

YEAR: 2006

Difference in Japanese flounder, Paralichthys olivaceus gene expression profile following hirame rhabdovirus (HIRRV) G and N protein DNA vaccination. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan.

Country: England

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MEDLINETA: Fish Shellfish Immunol

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