[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons]

[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons] Research Abstract Details 

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[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons] Abstract Text:

Wei Liu,Jian-Quan Zheng,Zhen-Wei Liu,Li-Jun Li,Qin Wan,Chuan-Gui Liu,

To compare the difference in action sites between mecamylamine (MEC) and hexamethonium (HEX) on nicotinic receptors of sympathetic neurons, we investigated the effects of MEC and HEX on the nicotine-induced currents in cultured superior cervical ganglion neurons by whole-cell patch clamp technique. The IC(50) of MEC and HEX for antagonizing the effect of 0.08 mmol/L nicotine was 0.0012 and 0.0095 mmol/L, respectively. Both MEC and HEX accelerated the desensitization of nicotinic receptors. Furthermore, by comparing their effects at holding potentials 30, 70 and 110 mV, it was indicated that their suppressing effect on the nicotine-induced currents was voltage-dependent. However, different from that of HEX, the inhibitory effect of MEC increased with administering the mixture of MEC and nicotine at intervals of 3 min, indicating a use-dependent effect of MEC. It is concluded that the action site of MEC on nicotinic receptors of sympathetic neurons is different from that of HEX.

[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons] Publishing Authors By Initials

W Liu,JQ Zheng,ZW Liu,LJ Li,Q Wan,CG Liu,

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[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 54

Page Numbers: 497-500

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ISSN: 0371-0874

DAY: 25

MONTH: Dec

YEAR: 2002

[Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons] Information

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LANGUAGE: chi

NlmUniqueID: 20730130

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Grant and Affiliation Information for [Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons]

AFFILIATION: 88 Hospital of Jinan Military Region, Taian 271000.

Country: China

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MEDLINETA: Sheng Li Xue Bao

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