Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size.

Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Research Abstract Details 

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Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Abstract Text:

Lev A Zhivotovsky,Peter A Underhill,Marcus W Feldman,

Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller.

Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Publishing Authors By Initials

LA Zhivotovsky,PA Underhill,MW Feldman,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular biology and evolution

VOLUME: 23

Page Numbers: 2268-70

Journal Abbreviation: Mol. Biol. Evol.

ISSN: 0737-4038

DAY: 6

MONTH: 09

YEAR: 2006

Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Information

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LANGUAGE: eng

NlmUniqueID: 8501455

Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: physiology

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Grant and Affiliation Information for Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size.

AFFILIATION: N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. levazh@gmail.com

Country: United States

AGENCY: United States NIGMS

GRANT: GM 28016

ACRONYM: GM

MEDLINETA: Mol Biol Evol

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