Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure.

Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Research Abstract Details 

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Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Abstract Text:

Amy R Scholik,Ung-Soo Lee,Ching K Chow,Hong Y Yan,

The fathead minnow (Pimephales promelas) was employed to examine if dietary vitamin E supplementation could protect the inner ear from the deleterious effects of noise. Fish were fed one of the three experimental diets containing either: (1) low vitamin E content (14.5 mg/kg diet as alpha-tocopheryl acetate), (2) an adequate amount of vitamin E (50 mg/kg), or (3) high vitamin E content (450 mg/kg). After 4 weeks on the diet, fish were exposed to either 2 or 24 h of intense white noise (142 dB re: 1 microPa, bandwidth 0.3-4.0 kHz). Auditory thresholds were measured, using the auditory brainstem response (ABR) technique, within 0.5 days following noise exposure or within a recovery period of 1.5 days. Additionally, liver samples were analyzed for vitamin E content. Increased vitamin E supplementation was dose-dependently associated with a reduction in statistically significant threshold shifts after noise exposure and an enhancement of recovery (i.e., more complete recovery over a shorter period) for fish exposed to either 2 or 24 h of noise. The results obtained suggest that dietary vitamin E affords protection against noise exposure in a cyprinid fish.

Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Publishing Authors By Initials

AR Scholik,US Lee,CK Chow,HY Yan,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Comparative biochemistry and physiology. Toxicolog

VOLUME: 137

Page Numbers: 313-23

Journal Abbreviation: Comp. Biochem. Physiol. C Toxi

ISSN: 1532-0456

DAY: 19

MONTH: Apr

YEAR: 2004

Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Information

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LANGUAGE: eng

NlmUniqueID: 100959500

Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Dietary vitamin E protects the fathead minnow, Pimephales promelas, against noise exposure.

AFFILIATION: Mechanosensory Physiology Laboratory, School of Biological Sciences, University of Kentucky, Lexington, KY 40506-0225, USA. ascholik@geo-marine.com

Country: United States

AGENCY: United States NIMH

GRANT: MH-58198

ACRONYM: MH

MEDLINETA: Comp Biochem Physiol C Toxicol

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