Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. Research Abstract Details 

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Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. Abstract Text:

Nguyet-Thin Luu,Jackie Madden,Philip C Calder,Robert F Grimble,Cliff P Shearman,Tim Chan,Neville Dastur,William M Howell,G Ed Rainger,Gerard B Nash,Nguyet-Thin Luu,Jackie Madden,Philip C Calder,Robert F Grimble,Cliff P Shearman,Tim Chan,Neville Dastur,William M Howell,G Ed Rainger,Gerard B Nash,

Monocytes/macrophages are key orchestrators of inflammation and are involved in the pathogenesis of chronic inflammatory disorders, including atherosclerosis. (n-3) Fatty acids, found in fish oil, have been shown to have protective effects in such disorders. To investigate possible modes of action, we used a monocyte:endothelial cell (EC) coculture model to investigate the pro-inflammatory potential of monocytes. Monocytes were isolated from the blood of donors with peripheral arterial disease (PAD) or control donors, before and after a 12-wk supplementation of their diet with fish oil. The monocytes were cultured with human umbilical vein EC (HUVEC) for 24 h, after which the ability of the HUVEC to recruit flowing neutrophils was tested. Monocytes from either group of donors stimulated the EC to support the adhesion and migration of neutrophils. Fish oil supplementation reduced the potency of monocytes from normal subjects, but not those from patients with PAD, to induce recruitment. Concurrent medication may have acted as a complicating factor. On subgroup analysis, only those free of medication showed a significant effect of fish oil. Responses before or after supplementation were not closely linked to patterns of secretion of cytokines by cultured monocytes, tested in parallel monocultures. These results suggest that fish oil can modulate the ability of monocytes to stimulate EC and that this might contribute to their protective effects against chronic inflammatory disorders. Benefits, however, may depend on existing medical status and on other treatments being received.

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. Publishing Authors By Initials

NT Luu,J Madden,PC Calder,RF Grimble,CP Shearman,T Chan,N Dastur,WM Howell,GE Rainger,GB Nash,NT Luu,J Madden,PC Calder,RF Grimble,CP Shearman,T Chan,N Dastur,WM Howell,GE Rainger,GB Nash,

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Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of nutrition

VOLUME: 137

Page Numbers: 2769-74

Journal Abbreviation: J. Nutr.

ISSN: 1541-6100

DAY: 21

MONTH: Dec

YEAR: 2007

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response. Information

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LANGUAGE: eng

NlmUniqueID: 404243

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AFFILIATION: Centre for Cardiovascular Sciences, Department of Physiology, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK.

Country: United States

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MEDLINETA: J Nutr

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