Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Abstract Text:

Donna L Perry,Jennifer M Spedick,Thomas P McCoy,Michael R Adams,Adrian A Franke,J Mark Cline,

Short-term dietary studies of soy-protein-derived isoflavonoids, using rodent and nonhuman primate models, have documented variable effects on the reproductive tract. Long-term effects of dietary soy and/or isoflavonoids on the reproductive tract of nonhuman primates have not been determined. The objective of this study was to assess the effects of long-term consumption of dietary soy isoflavonoids on histomorphology of the mammary glands and prostate gland, testis, and sperm counts in adult male cynomolgus macaques. Ninety-one adult male cynomolgus macaques (Macaca fascicularis) were fed diets for 3 y differing only in protein source: 1) a soy-free, casein-lactalbumin-based diet or 2) a low-soy isoflavonoid diet ( approximately 6 mg . kg(-1) . d(-1)) or 3) a high-soy isoflavonoid diet ( approximately 12 mg . kg(-1) . d(-1)). Serum isoflavonoids were measured by liquid chromatographic-photodiode array electrospray MS. Mammary gland, prostate gland, and testes were obtained at postmortem and evaluated histopathologically and histomorphometrically. Epididymal and testicular sperm counts were performed. Serum isoflavonoid concentrations at 4 h postfeeding differed among all groups (P < 0.001) and were (means +/- SEM) 67 +/- 23 (soy-free diet), 799 +/- 44 (low-soy isoflavonoid diet), and 1458 +/- 80 nmol . L(-1) (high-soy isoflavonoid diet). Diet did not alter serum estradiol and testosterone concentrations or epididymal and testicular sperm counts. Organ weights and histologic indices did not differ among treatment groups. Mammary gland histopathologic and histomorphometric analysis revealed no abnormalities and no indication of gynecomastia. We found no evidence of an adverse effect of soy isoflavonoids at physiologically relevant doses within the reproductive organs of adult male macaques.

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Publishing Authors By Initials

DL Perry,JM Spedick,TP McCoy,MR Adams,AA Franke,JM Cline,

For similar urogenital system: genitalia: genitalia, male: testis research abstracts see: urogenital system: genitalia: genitalia, male: testis research

PUBMED ID PMID:

MEDLINE DATE:

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of nutrition

VOLUME: 137

Page Numbers: 1390-4

Journal Abbreviation: J. Nutr.

ISSN: 0022-3166

DAY: 3

MONTH: Jun

YEAR: 2007

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404243

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Keywords Mesh Terms:

KEYWORDS: Testis

MESH TERMS: drug effects

Chemical & Substance for Abstract: Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). Information

Substance Name: Soybean Proteins

Registry Number: 0

Grant and Affiliation Information for Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).

AFFILIATION: Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. dlperry@wfubmc.edu

Country: United States

AGENCY: United States NCRR

GRANT: T32 RR07009

ACRONYM: RR

MEDLINETA: J Nutr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques Macaca fascicularis Related Publications

• 3DFT MR angiography of carotid and basilar arteries.
• A correlated study of tuberculin, histoplasmin and coccidioidin sensitivities with pulmonary calcifications in the Rocky Mountain area.
• A day in the life of an orthodontic assistant.
• Adrenal steroids in leukemia and lymphoma.
• Biotechnology and the new right: a progressive red herring?
• Cesium-137 movement in a root-soil profile. BNWL-480.
• Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.
• Decreases in plasma volume during electrically induced convulsions in man.
• Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis).
• Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys.
• Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model.
• Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys.
• Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
• Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys.
• Gold foil; the class five restoration.
• Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys.
• Insertion of drug resistance genes in animals.
• Mammary gland development in early pubertal female macaques.
• Radioiodine environment release studies. BNWL-280.
• Reaching kids with reactive attachment disorder.
• Refining the roles of GABAergic signaling during neural circuit formation.
• Roles of NR2A and NR2B in the Development of Dendritic Arbor Morphology In Vivo.
• Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys.
• Technology and outpatient review: a preliminary evaluation.
• The management of retained placenta; a plea for manual removal.
• The menace of socialized medicine.
• The thylakoid proton gradient promotes an advanced stage of signal peptide binding deep within the Tat pathway receptor complex.
• [Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)]
• [Incidence and clinical features of arrhythmias after surgical treatment of congenital heart disease]
• beta-Melanocyte-Stimulating Hormone Potently Reduces Appetite Via the Hypothalamus in Chicks.