Dietary restriction and aging.

Dietary restriction and aging. Research Abstract Details 

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Dietary restriction and aging. Abstract Text:

The diet-restricted rodent model has been and is a major tool in experimental biogerontology. A spectrum of findings indicates that dietary restriction retards the aging processes of mice and rats, the most salient of which is the increase in mortality rate doubling time. It also maintains many physiological processes in a youthful state and, most strikingly, retards or prevents almost all age-associated disease processes. Current emphasis is on the mechanisms underlying the anti-aging actions of dietary restriction. The major effort for determining mechanism has focused on putative primary aging processes. A clue has emerged from the findings that it is the restriction of energy intake that is the dietary factor responsible for the anti-aging actions. However, reducing the metabolic rate is not involved. The challenge is to learn how the reduction of energy intake per animal (not per unit of body mass) is coupled to the retardation of aging processes. One of our working hypotheses is that dietary restriction alters nervous and/or endocrine functions that influence the characteristics (not the rate) of fuel use; this modulation in fuel-use characteristics is proposed to retard the aging processes. Our findings on carbohydrate metabolism are in accord with this view. Diet-restricted rats can use carbohydrate fuel as effectively as ad libitum fed rats while maintaining lower plasma glucose and insulin level. Maintenance of these low levels may protect against long-term damaging actions of these substances. Dietary restriction also protects against oxidative damage and, of course, oxidative damage is probably an inevitable component of fuel use.(ABSTRACT TRUNCATED AT 250 WORDS)

Dietary restriction and aging. Publishing Authors By Initials

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Dietary restriction and aging. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of the American Geriatrics Society

VOLUME: 41

Page Numbers: 994-9

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Sep

YEAR: 1993

Dietary restriction and aging. Information

Number of References: 52

LANGUAGE: eng

NlmUniqueID: 7503062

Dietary restriction and aging. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Dietary restriction and aging. Information

Substance Name: Corticosterone

Registry Number: 50-22-6

Grant and Affiliation Information for Dietary restriction and aging.

AFFILIATION: Department of Physiology and Aging Research, University of Texas Health Science Center at San Antonio 78284-7756.

Country: UNITED STATES

AGENCY: United States NIA

GRANT: AG-01188

ACRONYM: AG

MEDLINETA: J Am Geriatr Soc

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