Dietary intakes of flavonols and flavones and coronary heart disease in US women.

Dietary intakes of flavonols and flavones and coronary heart disease in US women. Research Abstract Details 

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Dietary intakes of flavonols and flavones and coronary heart disease in US women. Abstract Text:

Jennifer Lin,Kathy M Rexrode,Frank Hu,Christine M Albert,Claudia U Chae,Eric B Rimm,Meir J Stampfer,JoAnn E Manson,

Dietary flavonols and flavones are subgroups of flavonoids that have been suggested to decrease the risk of coronary heart disease (CHD). The authors prospectively evaluated intakes of flavonols and flavones in relation to risk of nonfatal myocardial infarction and fatal CHD in the Nurses' Health Study. They assessed dietary information from the study's 1990, 1994, and 1998 food frequency questionnaires and computed cumulative average intakes of flavonols and flavones. Cox proportional hazards regression with time-varying variables was used for analysis. During 12 years of follow-up (1990-2002), the authors documented 938 nonfatal myocardial infarctions and 324 CHD deaths among 66,360 women. They observed no association between flavonol or flavone intake and risk of nonfatal myocardial infarction or fatal CHD. However, a weak risk reduction for CHD death was found among women with a higher intake of kaempferol, an individual flavonol found primarily in broccoli and tea. Women in the highest quintile of kaempferol intake relative to those in the lowest had a multivariate relative risk of 0.66 (95% confidence interval: 0.48, 0.93; p for trend = 0.04). The lower risk associated with kaempferol intake was probably attributable to broccoli consumption. These prospective data do not support an inverse association between flavonol or flavone intake and CHD risk.

Dietary intakes of flavonols and flavones and coronary heart disease in US women. Publishing Authors By Initials

J Lin,KM Rexrode,F Hu,CM Albert,CU Chae,EB Rimm,MJ Stampfer,JE Manson,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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Dietary intakes of flavonols and flavones and coronary heart disease in US women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of epidemiology

VOLUME: 165

Page Numbers: 1305-13

Journal Abbreviation: Am. J. Epidemiol.

ISSN: 0002-9262

DAY: 22

MONTH: 03

YEAR: 2007

Dietary intakes of flavonols and flavones and coronary heart disease in US women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7910653

Dietary intakes of flavonols and flavones and coronary heart disease in US women. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Dietary intakes of flavonols and flavones and coronary heart disease in US women. Information

Substance Name: kaempferol

Registry Number: 520-18-3

Grant and Affiliation Information for Dietary intakes of flavonols and flavones and coronary heart disease in US women.

AFFILIATION: Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL34594

ACRONYM: HL

MEDLINETA: Am J Epidemiol

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