Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions.

Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Research Abstract Details 

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Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Abstract Text:

Chantal M C Dupasquier,Elena Dibrov,Annette L Kneesh,Paul K M Cheung,Kaitlin G Y Lee,Helen K Alexander,Behzad K Yeganeh,Mohammed H Moghadasian,Grant N Pierce,Chantal M C Dupasquier,Elena Dibrov,Annette L Kneesh,Paul K M Cheung,Kaitlin G Y Lee,Helen K Alexander,Behzad K Yeganeh,Mohammed H Moghadasian,Grant N Pierce,

Dietary flaxseed has been shown to have potent antiatherogenic effects in rabbits. The purpose of the present study was to investigate the antiatherogenic capacity of flaxseed in an animal model that more closely represents the human atherosclerotic condition, the LDL receptor-deficient mouse (LDLrKO), and to identify the cellular mechanisms for these effects. LDLrKO mice were administered a regular diet (RG), a 10% flaxseed-supplemented diet (FX), or an atherogenic diet containing 2% cholesterol alone (CH) or supplemented with 10% flaxseed (CF), 5% flaxseed (CF5), 1% flaxseed (CF1), or 5% coconut oil (CS) for 24 wk. LDLrKO mice fed a cholesterol-supplemented diet exhibited a rise in plasma cholesterol without a change in triglycerides and an increase in atherosclerotic plaque formation. The CS mice exhibited elevated levels of plasma cholesterol, triglycerides, and saturated fatty acids and an increase in plaque development. Supplementation of the cholesterol-enriched diet with 10% (wt/wt) ground flaxseed lowered plasma cholesterol and saturated fatty acids, increased plasma ALA, and inhibited plaque formation in the aorta and aortic sinus compared with mice fed a diet supplemented with only dietary cholesterol. The expression of proliferating cell nuclear antigen (PCNA) and the inflammatory markers IL-6, mac-3, and VCAM-1 was increased in aortic tissue from CH and CS mice. This expression was significantly reduced or normalized when flaxseed was included in the diet. Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions.

Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Publishing Authors By Initials

CM Dupasquier,E Dibrov,AL Kneesh,PK Cheung,KG Lee,HK Alexander,BK Yeganeh,MH Moghadasian,GN Pierce,CM Dupasquier,E Dibrov,AL Kneesh,PK Cheung,KG Lee,HK Alexander,BK Yeganeh,MH Moghadasian,GN Pierce,

For similar membrane glycoproteins: cell adhesion molecules: vascular cell adhesion molecule-1 research abstracts see: membrane glycoproteins: cell adhesion molecules: vascular cell adhesion molecule-1 research

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Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Heart and circulat

VOLUME: 293

Page Numbers: H2394-402

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 6

MONTH: 07

YEAR: 2007

Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Information

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LANGUAGE: eng

NlmUniqueID: 100901228

Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Keywords Mesh Terms:

KEYWORDS: Vascular Cell Adhesion Molecule-1

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Information

Substance Name: monocyte-macrophage differentiation anti

Registry Number: 0

Grant and Affiliation Information for Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions.

AFFILIATION: Canadian Center for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Center, Winnipeg, Canada.

Country: United States

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MEDLINETA: Am J Physiol Heart Circ Physio

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