Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era.

Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Research Abstract Details 

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Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Abstract Text:

Tisha Joy,Hester M Keogh,Colleen Hadigan,Hang Lee,Sara E Dolan,Kathleen Fitch,James Liebau,Janet Lo,Stine Johnsen,Jane Hubbard,Ellen J Anderson,Steven Grinspoon,

OBJECTIVE: To evaluate dietary intake and its relationship to lipid parameters in HIV-infected patients with metabolic abnormalities. METHOD: We prospectively determined dietary intake (4-day food records or 24-h recall) in 356 HIV-infected patients and 162 community-derived HIV-negative controls evaluated for metabolic studies between 1998-2005. Differences in dietary intake between HIV-infected patients and non-HIV-infected controls, in relation to the established 2005 USDA (United States Department of Agriculture) Recommended Dietary Guidelines, were determined. The relationship between dietary fat intake and serum lipid levels among HIV-infected individuals was also evaluated. RESULTS: Assessment of dietary intake in this group of HIV-infected patients demonstrated increased intake of total dietary fat (P < 0.05), saturated fat (P = 0.006), and cholesterol (P = 0.006) as well as a greater percentage of calories from saturated fat (P = 0.002) and from trans fat (P = 0.02), despite similar caloric intake to the control individuals. A significantly higher percentage of HIV-infected patients were above the 2005 USDA Recommended Dietary Guidelines for saturated fat (> 10%/day) (76.0% HIV vs. 60.9% controls, P = 0.003), and cholesterol (> 300 mg/day) (49.7% HIV vs. 37.9% controls, P = 0.04). Saturated fat intake was strongly associated with triglyceride level [triglyceride level increased 8.7 mg/dl (parameter estimate) per gram of increased saturated fat intake, P = 0.005] whereas total fat was inversely associated with triglyceride level [triglyceride level decreased 3.0 mg/dl (parameter estimate) per gram of increased total fat intake, P = 0.02] among HIV-infected individuals. CONCLUSIONS: Increased intake of saturated fat is seen and contributes to hypertriglyceridemia among HIV-infected patients who have developed metabolic abnormalities. Increased saturated fat intake should be targeted for dietary modification in this population.

Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Publishing Authors By Initials

T Joy,HM Keogh,C Hadigan,H Lee,SE Dolan,K Fitch,J Liebau,J Lo,S Johnsen,J Hubbard,EJ Anderson,S Grinspoon,

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Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AIDS (London, England)

VOLUME: 21

Page Numbers: 1591-600

Journal Abbreviation: AIDS

ISSN: 0269-9370

DAY: 31

MONTH: Jul

YEAR: 2007

Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Information

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LANGUAGE: eng

NlmUniqueID: 8710219

Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Keywords Mesh Terms:

KEYWORDS: Socioeconomic Factors

MESH TERMS: blood

Chemical & Substance for Abstract: Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era. Information

Substance Name: Lipids

Registry Number: 0

Grant and Affiliation Information for Dietary fat intake and relationship to serum lipid levels in HIV-infected patients with metabolic abnormalities in the HAART era.

AFFILIATION: Program in Nutritional Metabolism, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Country: England

AGENCY: United States NICHD

GRANT: T32 HD 052961

ACRONYM: HD

MEDLINETA: AIDS

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