Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice.

Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Research Abstract Details 

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Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Abstract Text:

Kotaro Yamada,Masaya Hosokawa,Chizumi Yamada,Rie Watanabe,Shimpei Fujimoto,Hideya Fujiwara,Masaru Kunitomo,Toshihiro Miura,Tetsuo Kaneko,Kinsuke Tsuda,Yutaka Seino,Nobuya Inagaki,

Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR)alpha in liver and PPARgamma in WAT. This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPARalpha in liver and PPARgamma in WAT.

Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Publishing Authors By Initials

K Yamada,M Hosokawa,C Yamada,R Watanabe,S Fujimoto,H Fujiwara,M Kunitomo,T Miura,T Kaneko,K Tsuda,Y Seino,N Inagaki,

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Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 31

Page Numbers: 651-5

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 1

MONTH: Apr

YEAR: 2008

Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice. Information

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LANGUAGE: eng

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AFFILIATION: Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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