Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice.

Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Research Abstract Details 

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Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Abstract Text:

Ahmed N Uddin,Fredric J Burns,Toby G Rossman,Haobin Chen,Thomas Kluz,Max Costa,

The skin cancer enhancing effect of chromium (in male mice) and nickel in UVR-irradiated female Skh1 mice was investigated. The dietary vitamin E and selenomethionine were tested for prevention of chromium-enhanced skin carcinogenesis. The mice were exposed to UVR (1.0 kJ/m(2) 3 x weekly) for 26 weeks either alone, or combined with 2.5 or 5.0 ppm potassium chromate, or with 20, 100 or 500 ppm nickel chloride in drinking water. Vitamin E or selenomethionine was added to the lab chow for 29 weeks beginning 3 weeks before the start of UVR exposure. Both chromium and nickel significantly increased the UVR-induced skin cancer yield in mice. In male Skh1 mice, UVR alone induced 1.9+/-0.4 cancers/mouse, and 2.5 or 5.0 ppm potassium chromate added to drinking water increased the yields to 5.9+/-0.8 and 8.6+/-0.9 cancers/mouse, respectively. In female Skh1 mice, UVR alone induced 1.7+/-0.4 cancers/mouse, and the addition of 20, 100 or 500 ppm nickel chloride increased the yields to 2.8+/-0.9, 5.6+/-0.7 and 4.2+/-1.0 cancers/mouse, respectively. Neither vitamin E nor selenomethionine reduced the cancer yield enhancement by chromium. These results confirm that chromium and nickel, while not good skin carcinogens per se, are enhancers of UVR-induced skin cancers in Skh1 mice. Data also suggest that the enhancement of UVR-induced skin cancers by chromate may not be oxidatively mediated since the antioxidant vitamin E as well as selenomethionine, found to prevent arsenite-enhanced skin carcinogenesis, failed to suppress enhancement by chromate.

Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Publishing Authors By Initials

AN Uddin,FJ Burns,TG Rossman,H Chen,T Kluz,M Costa,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research

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Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Toxicology and applied pharmacology

VOLUME: 221

Page Numbers: 329-38

Journal Abbreviation: Toxicol. Appl. Pharmacol.

ISSN: 0041-008X

DAY: 14

MONTH: 04

YEAR: 2007

Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 416575

Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Keywords Mesh Terms:

KEYWORDS: Ultraviolet Rays

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Information

Substance Name: Nickel

Registry Number: 7440-02-0

Grant and Affiliation Information for Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice.

AFFILIATION: Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: ES10344

ACRONYM: ES

MEDLINETA: Toxicol Appl Pharmacol

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