Dialysis membrane-induced oxidative stress: role of heme oxygenase-1.

Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Research Abstract Details 

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Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Abstract Text:

Madhu Bhaskaran,Neetu Radhakrishnan,Hitesh Patni,Priyanka Singh,Ahmad N Chaudhary,Pravin C Singhal,

Dialysis membranes have been reported to induce monocyte apoptosis. We studied the role of oxidative stress in the induction of dialysis membrane-induced monocyte apoptosis. Superoxide dismutase, a superoxide scavenger, prevented dialysis membrane-induced monocyte apoptosis. Similarly, other antioxidants also inhibited dialysis membrane- induced apoptosis. In addition, the interaction of dialysis membranes with monocytes was associated with the generation of molecules leading to oxidative stress such as superoxide and TBARS. Interestingly, pre-induction of heme oxygenase (HO)-1 by hemin prevented dialysis membrane-induced monocyte apoptosis, whereas inhibition of HO-1 activity (treatment with tin protoporphyrin, SN-P) enhanced dialysis membrane-induced monocyte apoptosis. We suggest that oxidative injury associated with dialysis membrane and monocyte interaction plays a role in monocyte injury. Pre-induction of HO-1 may attenuate dialysis membrane-induced monocyte apoptosis.

Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Publishing Authors By Initials

M Bhaskaran,N Radhakrishnan,H Patni,P Singh,AN Chaudhary,PC Singhal,

For similar inorganic chemicals: electrolytes: ions: anions: oxides: peroxides: superoxides research abstracts see: inorganic chemicals: electrolytes: ions: anions: oxides: peroxides: superoxides research

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MEDLINE DATE:

Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nephron. Experimental nephrology

VOLUME: 105

Page Numbers: e24-32

Journal Abbreviation: Nephron Exp. Nephrol.

ISSN: 1660-2129

DAY: 13

MONTH: 11

YEAR: 2006

Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101159770

Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Keywords Mesh Terms:

KEYWORDS: Superoxides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Dialysis membrane-induced oxidative stress: role of heme oxygenase-1. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for Dialysis membrane-induced oxidative stress: role of heme oxygenase-1.

AFFILIATION: Division of Kidney Diseases and Hypertension, North Shore University Hospital, Manhasset and Long Island Jewish Medical Center, New Hyde Park, NY, USA.

Country: Switzerland

AGENCY: United States NIDA

GRANT: R01-DA12111

ACRONYM: DA

MEDLINETA: Nephron Exp Nephrol

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